Evaluating Pericoronary Adipose Tissue Attenuation to Predict Cardiovascular Events

JACC. Asia Pub Date : 2025-01-01 DOI:10.1016/j.jacasi.2024.09.009

Takahiro Nishihara MD, PhD , Toru Miyoshi MD, PhD , Kentaro Ejiri MD, PhD , Kazuhiro Osawa MD, PhD , Soichiro Fuke MD, PhD , Kousuke Seiyama MD , Masayuki Doi MD, PhD , Mitsutaka Nakashima MD, PhD , Takashi Miki MD, PhD , Shinsuke Yuasa MD, PhD

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Abstract

Background

Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian ethnicity.

Objectives

This multicenter study aimed to evaluate the effect of PCATA on prognosis in East Asian patients.

Methods

Between August 2011 and December 2016, 2,172 patients underwent clinically indicated coronary computed tomography angiography (CTA) at 4 hospitals in Japan. Among them, 1,270 patients were analyzed. PCATA was evaluated using coronary CTA to measure pericoronary adipose tissue density surrounding the 3 major coronary arteries. The outcomes were composite cardiovascular events, including cardiovascular death and acute coronary syndrome; 33 cardiovascular events observed during a median follow-up of 6.0 years (Q1-Q3: 3.6-8.2 years).

Results

Right coronary artery (RCA)-PCATA was significantly higher in patients with cardiovascular events than in those without (−63.7 ± 8.9 HU vs −67.4 ± 9.1 HU, respectively; P = 0.021). High RCA-PCATA was significantly associated with cardiovascular events in a model that included the Hisayama risk score and adverse coronary CTA findings (HR: 1.55; 95% CI: 1.07-2.24; P = 0.019).

Conclusions

High RCA-PCATA showed significant association with future cardiovascular events after adjusting conventional risk factors and adverse coronary CTA findings in East Asian patients who underwent clinically indicated coronary CTA.

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评估冠状动脉周围脂肪组织衰减预测心血管事件：一项东亚多中心研究。

背景：冠状动脉周围脂肪组织衰减（PCATA）是与冠状动脉疾病相关的冠状动脉周围炎症的一种新的成像生物标志物。几项研究报告了PCATA在欧洲人中的有效性；然而，缺乏有关亚洲族裔的数据。目的：本多中心研究旨在评估PCATA对东亚患者预后的影响。方法：2011年8月至2016年12月，2172名患者在日本4家医院接受了临床指示的冠状动脉ct血管造影（CTA）。其中对1270例患者进行了分析。通过冠状动脉CTA测量3条主要冠状动脉周围的冠状动脉脂肪组织密度来评估PCATA。结果为复合心血管事件，包括心血管死亡和急性冠状动脉综合征；在中位随访6.0年期间观察到33例心血管事件（Q1-Q3: 3.6-8.2年）。结果：有心血管事件的患者右冠状动脉(RCA)-PCATA明显高于无心血管事件的患者（-63.7±8.9 HU vs -67.4±9.1 HU）；P = 0.021)。在包括Hisayama风险评分和不良冠状动脉CTA结果的模型中，高RCA-PCATA与心血管事件显著相关(HR: 1.55；95% ci: 1.07-2.24；P = 0.019)。结论：在接受临床指示的冠状动脉CTA的东亚患者中，在调整常规危险因素和不良冠状动脉CTA结果后，高RCA-PCATA与未来心血管事件有显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC. Asia Cardiology and Cardiovascular Medicine

CiteScore

4.00

自引率

0.00%

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