Effect of acute ethanol intoxication on swallowing function in mice

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY

Auris Nasus Larynx Pub Date : 2025-01-30 DOI:10.1016/j.anl.2025.01.004

Takuma Hisaoka , Jun Suzuki , Ryoukichi Ikeda , Jun Ohta , Hiyori Takahashi , Yukio Katori

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引用次数: 0

Abstract

Objectives

Ethanol consumption may lead to various symptoms depending on its concentration in the blood. Acute ethanol intoxication is a major risk factor for bolus -aspiration; however, studies on the effects of acute ethanol intoxication on swallowing are lacking. Therefore, we investigated the effect of acute ethanol intoxication on mice using the videofluoroscopic swallowing study (VFSS) methodology.

Methods

Male C57BL/6 J mice were randomly allocated into three groups: saline injection, 2 g/kg ethanol injection, and 4 g/kg ethanol injection. The VFSS technique was used to analyze the inter-swallow interval, lick-swallow rate, lick rate, bolus area, pharyngeal transit time, bolus speed, and bolus area 3 d before injection (control), 2 h after injection, and 8 h after injection.

Results

In the 4 g/kg ethanol injection group, the inter-swallow interval and lick-swallow rate increased after 2 h However, these changes were reversed 8 h after ethanol administration. Additionally, the pharyngeal transit time, bolus speed, and bolus area did not change significantly after ethanol administration.

Conclusions

The present study reveals that ethanol administration delays bolus transport in the mouth but does not affect pharyngeal swallowing reflexes and reflex thresholds. Acute ethanol intoxication specifically impairs the oral function as assessed by the VFSS.

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.