Versatile nanomaterials used in combatting biofilm infections.

Abstract

Microbial infections are a pressing global health issue, exacerbated by the rise of antibiotic-resistant bacteria due to widespread antibiotic overuse. This resistance diminishes the effectiveness of current treatments, intensifying the need for new antimicrobial agents and innovative drug delivery strategies. Nanotechnology presents promising solutions, leveraging the unique properties of nanomaterials such as tunable optical and electronic characteristics, nanoscale size, and high surface-to-volume ratios. These features enhance their effectiveness as innovative antimicrobial agents and versatile drug delivery systems. This minireview classifies antimicrobial nanomaterials into four categories based on their mechanisms of action: thermal generation, reactive oxygen species generation, gas generation, and nanocarrier systems such as liposomes, polymersomes, and metal-organic frameworks. Uniquely, this review integrates a comparative analysis of these mechanisms, highlighting their relative advantages, limitations, and applications across diverse microbial targets. Additionally, it identifies emerging trends in the field, providing a forward-looking perspective on how recent advancements in nanotechnology can be leveraged to address unmet clinical needs. Finally, this article discusses future directions and emerging opportunities in antimicrobial nanotechnology.