Association of arterial structure and function with incident cardiovascular diseases and cognitive decline.

IF 4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI:10.1002/dad2.70069

Caroline Robert, Wei Ying Tan, Lieng-Hsi Ling, Saima Hilal

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引用次数: 0

Abstract

Introduction: We examined the associations of carotid intima-media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases (CVD) and dementia in the UK Biobank cohort.

Methods: The study consisted of 42,711 participants (mean age 64.2 years) with brain magnetic resonance imaging (MRI), vascular assessments, and cognitive testing. Cerebrovascular disease markers included white matter hyperintensities (WMH) and brain volumes. CIMT, ASI, and PP were measured using carotid ultrasound, photoplethysmography, and blood pressure, respectively. General cognitive ability (g-score) was derived from various cognitive tests using principal components analysis (PCA).

Results: Elevated CIMT, ASI, and PP were associated with increased WMH volume (WMHV). Increased PP was independently associated with poorer numeric memory (ß = -0.028,p = 0.002), fluid intelligence (IQ) (ß = -0.060,p < 0.001), and g-score (ß = -0.028,p < 0.001) in cross-sectional analysis, but not longitudinally. CIMT showed the strongest association with incident CVD and dementia.

Discussion: CIMT had the most robust associations with WMHV, incident CVD, and dementia, suggesting its utility as an alternative endpoint.

Highlights: Effects of arterial stiffness on cognition, dementia, and CVD.Structural vascular parameters included CIMT.Functional properties included ASI and PP.CIMT, ASI, and PP were positively associated with WMHV.CIMT had the greatest associations with incident CVD and dementia.

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动脉结构和功能与心血管疾病和认知能力下降的关系。

在英国生物银行队列中，我们研究了颈动脉内膜-中膜厚度（CIMT）、动脉硬度指数（ASI）和脉压（PP）与脑血管疾病、认知功能和衰退、心血管疾病（CVD）和痴呆的关系。方法：该研究包括42,711名参与者（平均年龄64.2岁），进行脑磁共振成像（MRI）、血管评估和认知测试。脑血管疾病的标志物包括白质高信号（WMH）和脑容量。CIMT、ASI和PP分别采用颈动脉超声、光容积描记术和血压测量。一般认知能力（g-score）采用主成分分析（PCA）从各种认知测试中得出。结果：CIMT、ASI和PP升高与WMHV升高相关。增加的PP与较差的数字记忆（ß = -0.028,p = 0.002）、流体智力（IQ） (ß = -0.060，p - g评分（ß = -0.028,p）独立相关。讨论：CIMT与WMHV、CVD事件和痴呆的相关性最强，表明其作为替代终点的效用。重点：动脉僵硬对认知、痴呆和心血管疾病的影响。结构血管参数包括CIMT。功能属性包括ASI和PP， cimt、ASI和PP与WMHV呈正相关。CIMT与CVD和痴呆的发生有最大的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.