Impacto de la atención farmacéutica en la adherencia a los inhibidores de la tirosin-cinasa en la leucemia mieloide crónica

IF 1.3 Q4 PHARMACOLOGY & PHARMACY

FARMACIA HOSPITALARIA Pub Date : 2025-07-01 DOI:10.1016/j.farma.2024.11.009

Betel Del Rosario García , María Micaela Viña Romero , Virginia González Rosa , Carolina Alarcón Payer , Leonor Oliva Oliva , Gloria Julia Nazco Casariego , Fernando Gutiérrez Nicolás

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引用次数: 0

Abstract

Aims

Tyrosine kinase inhibitors (TKIs) have been successful in changing the course of chronic myeloid leukaemia (CML) due to their high efficacy. However, their effectiveness is conditioned by adherence to treatment. The aim of this study was to analyse the adherence of CML patients treated with TKIs and to evaluate the impact of pharmaceutical care on adherence in a prospective and interventional manner.

Methods

Multicentre, prospective study including CML patients on treatment with TKIs attending the outpatient units of the Pharmacy Services. Adherence was assessed using a combination of two methods: the Simplified Adherence Problems Scale and the treatment dispensing register (a patient with a percentage < 90% being considered “non-adherent”); patients who demonstrated a non-adherence in either of these two methods were classified as “non-adherent patients”. In individuals with inadequate adherence, PC was reinforced for 8 months by means of a specific programme.

Results

A total of 130 patients were included, 56.9% had optimal adherence to treatment. Pharmaceutical care in the oncohaematology-specific outpatient units of the Pharmacy Services improved adherence (from 67.1% to 90.9%; p < 0.001) while the generalist outpatient units kept it constant (from 70.2% to 72.4%; p = 0.509).

Conclusions

Adherence is one of the most relevant parameters in the effectiveness of chronic treatments. Approximately half of our CML patients showed inadequate adherence to TKIs. This is the first prospective study to determine that the pharmacist's actions in oncohaematology-specific outpatient units of the Pharmacy Services are capable of influencing adherence and improving it.

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药学服务对慢性髓性白血病患者酪氨酸激酶抑制剂依从性的影响。

目的：酪氨酸激酶抑制剂（TKIs）已成功地改变慢性髓性白血病（CML）的进程，由于其高效率。然而，它们的有效性取决于坚持治疗。本研究的目的是分析接受TKIs治疗的CML患者的依从性，并以前瞻性和介入性的方式评估药学服务对依从性的影响。方法：多中心前瞻性研究，包括在药房门诊接受TKIs治疗的CML患者。依从性评估采用两种方法的组合：简化依从性问题量表和治疗配药登记（患者百分比）结果：共纳入130例患者，56.9%的患者对治疗的依从性最佳。药学服务部门血液肿瘤专科门诊的药学服务提高了依从性(从67.1%提高到90.9%；P < 0.001)，而全科门诊单位保持不变(从70.2%到72.4%；P = 0.509)。结论：依从性是慢性治疗有效性最相关的参数之一。大约一半的CML患者对tki的依从性不足。这是第一个前瞻性研究，以确定药剂师的行动在血液肿瘤专科门诊单位的药房服务能够影响和改善依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

FARMACIA HOSPITALARIA PHARMACOLOGY & PHARMACY-

CiteScore

1.90

自引率

21.40%

发文量

审稿时长

37 days

期刊介绍： Una gran revista para acceder a los mejores artículos originales y revisiones de la farmacoterapia actual. Además, es Órgano de expresión científica de la Sociedad Española de Farmacia Hospitalaria, y está indexada en Index Medicus/Medline, EMBASE/Excerpta Médica, Alert, Internacional Pharmaceutical Abstracts y SCOPUS.