Diagnostic Ability and Correlation of Digital ¹¹C-Methionine PET/CT in Primary Hyperparathyroidism with Inconclusive Standard Imaging.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine and Molecular Imaging Pub Date : 2025-02-01 Epub Date: 2024-08-22 DOI:10.1007/s13139-024-00878-x

Hee Beom Jeong, Yong-Il Kim, Soyoon Yoon, Dong Yun Lee, Beom-Jun Kim, Seung Hun Lee, Jin-Sook Ryu

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引用次数: 0

Abstract

Purpose: ¹¹C-Methionine PET/CT is a promising method for detecting parathyroid lesions in patients with primary hyperparathyroidism (PHPT). We aimed to determine the diagnostic ability and correlation of digital ¹¹C-Methionine PET/CT for parathyroid lesions in patients with PHPT, particularly in cases where standard imaging methods yielded inconclusive results.

Methods: This retrospective analysis was conducted on patients diagnosed with PHPT who underwent digital ¹¹C-Methionine PET/CT imaging because of ambiguous results on standard imaging work-up (^99mTc-MIBI parathyroid scan and/or neck ultrasonography). Quantitative ¹¹C-Methionine PET/CT parameters, including maximum standardized uptake value (SUVmax), mean SUV (SUVmean), peak SUV (SUVpeak), parathyroid methionine volume (PMV), and whole methionine uptake (WMU: PMV multiplied by SUVmean) were calculated with various thresholds, and their correlations with biochemical and pathologic parameters were investigated.

Results: This study included 22 consecutive patients (10 men and 12 women) with a median age of 64.0 years. The lesion detection rate and sensitivity of digital ¹¹C-Methionine PET/CT were 81.8% (18/22) and 100.0% (18/18), respectively. Quantitative analysis revealed that serum PTH (r = 0.490, P = 0.039) and serum calcium (r = 0.583, P = 0.011) were significantly correlated with PMV50%.

Conclusion: Digital ¹¹C-Methionine PET/CT offers good performance in the detection of parathyroid lesions in PHPT patients with inconclusive standard imaging work-up. The volume parameter of PMV50% significantly correlated biochemical parameters and can serve as a complementary diagnostic tool.

Supplementary information: The online version contains supplementary material available at 10.1007/s13139-024-00878-x.

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数字11c -蛋氨酸PET/CT对原发性甲状旁腺功能亢进标准影像不确定的诊断能力及相关性

目的：11c -蛋氨酸PET/CT检测原发性甲状旁腺功能亢进（PHPT）患者甲状旁腺病变是一种很有前途的方法。我们的目的是确定数字11c -蛋氨酸PET/CT对PHPT患者甲状旁腺病变的诊断能力和相关性，特别是在标准成像方法无法得出结论性结果的情况下。方法：回顾性分析诊断为PHPT的患者，由于标准影像学检查（99mTc-MIBI甲状旁腺扫描和/或颈部超声检查）结果不明确，接受11c -蛋氨酸PET/CT数字成像。以不同阈值计算11c -蛋氨酸PET/CT定量参数，包括最大标准化摄取值（SUVmax）、平均SUV （SUVmean）、峰值SUV （SUVpeak）、甲状旁腺蛋氨酸体积（PMV）、全蛋氨酸摄取（WMU: PMV乘以SUVmean），并探讨其与生化、病理参数的相关性。结果：本研究纳入22例连续患者（10男12女），中位年龄64.0岁。数字11c -蛋氨酸PET/CT病变检出率和灵敏度分别为81.8%（18/22）和100.0%（18/18）。定量分析显示血清PTH （r = 0.490, P = 0.039）、血清钙（r = 0.583, P = 0.011）与PMV50%有显著相关性。结论：数字11c -蛋氨酸PET/CT对标准影像学检查不确定的PHPT患者甲状旁腺病变有较好的检测效果。PMV50%体积参数与生化参数相关性显著，可作为辅助诊断工具。补充信息：在线版本包含补充资料，提供地址为10.1007/s13139-024-00878-x。

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来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.