Tolerability and effectiveness of face-masks in reducing cough aerosols for children with cystic fibrosis

IF 5.4 2区医学 Q1 RESPIRATORY SYSTEM

Journal of Cystic Fibrosis Pub Date : 2025-03-01 DOI:10.1016/j.jcf.2025.01.008

George T.P. Tay , Kim Smith , Congrong He , Emma L. Ballard , Michelle E. Wood , Rebecca E. Stockwell , Lidia Morawska , Claire E. Wainwright , Scott C. Bell

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引用次数: 0

Abstract

Background

People with cystic fibrosis (CF) are recommended to wear face-masks when in healthcare settings. We previously demonstrated that face-masks significantly reduce the release of Pseudomonas aeruginosa (P. aeruginosa) aerosols during coughing in adults with CF. There is a knowledge gap in relation to the impact of mask wear in children with CF. This study aimed to examine the tolerability and effectiveness in lowering emissions of hospital-grade surgical and one type of commercially available cotton face-mask in children with CF.

Methods

Twenty children with CF and P. aeruginosa infection were recruited. Participants performed three cough manoeuvres in a validated cough aerosol system both with and without face-masks of differing wear time. Cough aerosols were sampled at two meters using an Andersen Cascade Impactor. Quantitative sputum and aerosol bacterial cultures were performed. Participants also rated the comfort levels of the face-masks.

Results

P. aeruginosa was cultured from the sputum in eight participants (40 %). During uncovered coughing (reference manoeuvre), seven of the 20 participants produced aerosols containing bacterial pathogens. There was a reduction in aerosolised bacterial load during coughing with both surgical and cotton face-masks. The mean percent reduction in CFU with both types of face-masks was 82 % (95 % CI 56 - 108) during the immediate face-mask wear test compared to the uncovered cough test. Face-masks were generally well tolerated.

Conclusions

Face-masks are well tolerated and effective in reducing cough-generated bacterial aerosols in children with CF.

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面罩在减少囊性纤维化儿童咳嗽气溶胶中的耐受性和有效性。

背景：囊性纤维化（CF）患者在医疗机构建议戴口罩。我们之前的研究表明，口罩可以显著减少CF成人咳嗽时铜绿假单胞菌（P. aeruginosa）气溶胶的释放。关于CF儿童佩戴口罩的影响，目前还存在知识空白。本研究旨在检查医院级外科口罩和一种市售棉质口罩在降低CF儿童口罩排放方面的耐受性和有效性。招募了20名CF和铜绿假单胞菌感染的儿童。参与者在经过验证的咳嗽气雾剂系统中进行了三次咳嗽动作，分别戴和不戴不同佩戴时间的口罩。咳嗽气溶胶是用安德森级联撞击器在两米高空取样的。定量痰液和气溶胶细菌培养。参与者还对口罩的舒适度进行了评分。结果：从8例（40%）受试者的痰中培养出铜绿假单胞菌。在不暴露的咳嗽过程中（参考操作），20名参与者中有7人产生了含有细菌病原体的气溶胶。使用外科口罩和棉质口罩咳嗽时，雾化细菌负荷都有所减少。与无遮盖咳嗽测试相比，在立即佩戴口罩测试期间，两种类型口罩的CFU平均减少百分比为82% （95% CI 56 - 108）。人们对口罩的耐受性普遍良好。结论：口罩耐受性良好，可有效减少CF患儿咳嗽产生的细菌气溶胶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cystic Fibrosis 医学-呼吸系统

CiteScore

10.10

自引率

13.50%

发文量

1361

审稿时长

50 days

期刊介绍： The Journal of Cystic Fibrosis is the official journal of the European Cystic Fibrosis Society. The journal is devoted to promoting the research and treatment of cystic fibrosis. To this end the journal publishes original scientific articles, editorials, case reports, short communications and other information relevant to cystic fibrosis. The journal also publishes news and articles concerning the activities and policies of the ECFS as well as those of other societies related the ECFS.