The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model.

IF 3.6 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes Research Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.1155/jdr/6209785
Arafat Hassan Razon, Md Alauddin, Nisat Farzana, Sanaullah Mazumdar, Md Ruhul Amin, Md Mahedi Hassan Tusher, Md Asrafuzzaman, Nahid Hasan, Mahfuzur Rahman, Muhammad Saiedullah, Begum Rokeya, Md Omar Faruque
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引用次数: 0

Abstract

Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) functions to reduce hyperglycemia through insulin-independent pathways and protects beta-cells. Diabetic model rats were administered standard diets supplemented with 5% oyster mushroom powder (mushroom-treated (MT) group) and 5% fenugreek seed powder (fenugreek-treated (FT) group) for 8 weeks. The results showed improvements in both glycemic and lipid profiles, with both oyster mushroom and fenugreek enhancing the phosphorylation of AMPK in muscle tissue. However, no effect on insulin secretion was observed. These findings suggest that both substances reduce hyperglycemia through an insulin-independent pathway. In silico analysis of both mushroom and fenugreek seed extracts revealed bioactive compounds having a strong binding affinity to α-glucosidase, which suggests mushroom and fenugreek supplements might control postprandial blood glucose levels.

功能食品平菇和胡芦巴对2型糖尿病动物模型的复杂作用机制。
蘑菇和胡芦巴被广泛用于降低高血糖,胡芦巴也被用作烹饪原料,以提高风味和香气。本研究旨在探讨蘑菇和胡芦巴对2型糖尿病大鼠模型的降糖作用的潜在机制。腺苷单磷酸(AMP)活化蛋白激酶(AMPK)通过胰岛素非依赖性途径降低高血糖并保护β细胞。给糖尿病模型大鼠添加5%平菇粉(蘑菇处理(MT)组)和5%胡芦巴籽粉(胡芦巴处理(FT)组)的标准日粮8周。结果显示,平菇和胡芦巴都能提高肌肉组织中AMPK的磷酸化,从而改善血糖和脂质谱。然而,未观察到对胰岛素分泌的影响。这些发现表明,这两种物质通过胰岛素不依赖的途径降低高血糖。对香菇和胡芦巴籽提取物的硅分析显示,其生物活性化合物与α-葡萄糖苷酶具有很强的结合亲和力,这表明香菇和胡芦巴补充剂可能控制餐后血糖水平。
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来源期刊
Journal of Diabetes Research
Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
8.40
自引率
2.30%
发文量
152
审稿时长
14 weeks
期刊介绍: Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.
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