"Minimal-Advice" on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE

High Blood Pressure & Cardiovascular Prevention Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI:10.1007/s40292-025-00704-1

Lanfranco D'Elia, Pasquale Strazzullo, Antonio Del Giudice, Giovambattista Desideri, Rosario Di Quattro, Claudio Ferri, Alessandra Grossi, Lorenzo Malatino, Francesca Mallamaci, Andrea Maresca, Michele Meschi, Alessia Casola, Pietro Nazzaro, Marco Pappaccogli, Franco Rabbia, Carla Sala, Ferruccio Galletti

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引用次数: 0

Abstract

Introduction: A strong and well-known association exists between salt consumption, potassium intake, and cardiovascular diseases. MINISAL-SIIA results showed high salt and low potassium consumption in Italian hypertensive patients. In addition, a recent Italian survey showed that the degree of knowledge and behaviour about salt was directly interrelated, suggesting a key role of the educational approach.

Aim: The present multicentre randomised controlled trial study aimed to evaluate the efficacy of a short-time dietary educational intervention by a physician, only during the first visit, on sodium and potassium intake in hypertensive patients.

Methods: Two-hundred-thirty hypertensive subjects participating in the MINISAL-SIIA study were enrolled for this study. After the randomisation, the participants were stratified into the educational intervention (EI) group (n = 109) and control group (C) (n = 121). Anthropometric indexes and blood pressure (BP) measurements were taken in the single-centre, and 24-hour urinary sodium (UrNa) and potassium (UrK) excretion were centrally measured.

Results: After 3 months, there was a reduction in BP, UrNa, and body weight, and an increase in UrK in EI. By contrast, a lower decrease in BP was found in the C group, and a slight rise in UrNa and no substantial change in UrK were revealed. BP changes were positively and significantly associated with changes in UrNa only in EI.

Conclusion: The main results of this trial indicate that a single brief educational intervention by a physician can lead to a reduction in salt intake and BP, and increased potassium consumption in hypertensive patients, without adverse effects.

Trail registration: ClinicalTrial.gov registration number: NCT06651437.

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关于盐摄入量的“最低建议”：一项针对高血压患者的多中心随机对照试验的结果

简介：盐的摄入、钾的摄入和心血管疾病之间存在着强烈而众所周知的联系。mini - siia结果显示意大利高血压患者高盐低钾消耗。此外，意大利最近的一项调查显示，关于盐的知识和行为的程度是直接相关的，这表明教育方法的关键作用。目的：目前的多中心随机对照试验研究旨在评估医生在首次就诊时进行的短期饮食教育干预对高血压患者钠和钾摄入的效果。方法：230名参加MINISAL-SIIA研究的高血压患者被纳入本研究。随机化后，参与者被分为教育干预（EI）组（n = 109）和对照组(C) （n = 121）。单中心测量人体测量指标和血压（BP），集中测量24小时尿钠（UrNa）和尿钾（UrK）排泄量。结果：3个月后，患者血压、UrNa和体重下降，EI患者UrK升高。相比之下，C组血压下降幅度较小，UrNa略有升高，UrK无明显变化。BP变化仅在EI中与UrNa变化呈正相关。结论：本试验的主要结果表明，医生进行一次简短的教育干预可以减少高血压患者的盐摄入量和血压，并增加钾的消耗，而不会产生不良反应。试验注册：ClinicalTrial.gov注册号：NCT06651437。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.