Neurotrophins and their receptors in the peripheral nervous system and non-nervous tissue of fish.

IF 2.5 3区 农林科学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aldo Isaac Carrillo-Muñoz, Sharet Y R-Jaimes, Guadalupe C Hernández-Hernández, Francisco Castelán
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Abstract

Trophic factors, such as neurotrophins, are fundamental for cellular processes including differentiation, growth, survival, and regeneration. These molecules exhibit significant morphological and phylogenetic conservation throughout the animal kingdom, indicating conserved functions. In fish, the oldest and most diverse group of vertebrates, neurotrophins, and their receptors play pivotal roles not only within the central nervous system but also in various peripheral tissues. They are distributed in mechanosensory, muscle, skin, respiratory, circulatory, digestive, endocrine, urinary, reproductive, and immune systems, suggesting their involvement in the development and maintenance of all tissues/organs/systems. Despite this broad distribution, studies focusing on these molecules outside of the central nervous system have been limited to just 12 fish species. These investigations have revealed diverse expression patterns across different ages and tissues/organs/systems, expanding our comprehension of their functions beyond the central and peripheral nervous systems. Notably, BDNF and NT-3 are prominently expressed outside the central nervous system, particularly in mechanosensory and digestive tissues, whereas NGF is predominantly observed in mechanosensory and urinary systems. The expression and localization of neurotrophins and their receptors vary among organs, underscoring tissue-specific roles. Further research is imperative to decipher the precise functions and mechanisms of action of neurotrophins and their receptors in diverse fish tissues. Enhanced efforts are needed to include a broader range of fish species in these studies to advance our understanding of these agents in complex vertebrates, thereby shedding light on tissue development, regeneration, and maintenance, with potential implications for addressing organ-related issues.

鱼的周围神经系统和非神经组织中的神经营养因子及其受体。
营养因子,如神经营养因子,是细胞分化、生长、存活和再生过程的基础。这些分子在整个动物王国中表现出显著的形态和系统发育保守性,表明其功能保守。鱼类是最古老和最多样化的脊椎动物,神经营养因子及其受体不仅在中枢神经系统中起着关键作用,而且在各种外周组织中也起着关键作用。它们分布在机械感觉、肌肉、皮肤、呼吸、循环、消化、内分泌、泌尿、生殖和免疫系统中,表明它们参与所有组织/器官/系统的发育和维持。尽管分布广泛,但集中在中枢神经系统外的这些分子的研究仅限于12种鱼类。这些研究揭示了不同年龄和不同组织/器官/系统的不同表达模式,扩大了我们对其功能的理解,超出了中枢和周围神经系统。值得注意的是,BDNF和NT-3主要在中枢神经系统外表达,特别是在机械感觉和消化组织中,而NGF主要在机械感觉和泌尿系统中观察到。神经营养因子及其受体的表达和定位因器官而异,强调组织特异性作用。神经营养因子及其受体在各种鱼类组织中的确切功能和作用机制有待进一步研究。我们需要在这些研究中加入更广泛的鱼类物种,以提高我们对复杂脊椎动物中这些因子的理解,从而揭示组织发育、再生和维持,并对解决器官相关问题具有潜在的意义。
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来源期刊
Fish Physiology and Biochemistry
Fish Physiology and Biochemistry 农林科学-生化与分子生物学
CiteScore
5.60
自引率
6.90%
发文量
106
审稿时长
4 months
期刊介绍: Fish Physiology and Biochemistry is an international journal publishing original research papers in all aspects of the physiology and biochemistry of fishes. Coverage includes experimental work in such topics as biochemistry of organisms, organs, tissues and cells; structure of organs, tissues, cells and organelles related to their function; nutritional, osmotic, ionic, respiratory and excretory homeostasis; nerve and muscle physiology; endocrinology; reproductive physiology; energetics; biochemical and physiological effects of toxicants; molecular biology and biotechnology and more.
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