Predictive value of temporal muscle thickness for prognosis in newly diagnosed IDH wild-type glioblastoma patients: evaluated for a Chinese population.

IF 4.7 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
European Radiology Pub Date : 2025-08-01 Epub Date: 2025-01-31 DOI:10.1007/s00330-025-11394-7
Boya Zha, Yajing Ma, Boqun Zha, Xinbin Guo
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引用次数: 0

Abstract

Objectives: This study aims to investigate the prognostic value of Temporal Muscle Thickness (TMT) in Chinese patients with newly diagnosed isocitrate dehydrogenase (IDH) wild-type glioblastoma.

Methods: Data were retrospectively collected from patients with isocitrate dehydrogenase wild-type genotype glioblastoma, who underwent surgical treatment and concurrent chemoradiotherapy at our center between May 2019 and May 2023. Multi-model and multivariate Cox regression were used to examine factors associated with overall and progression-free survival. Subgroup analysis and sensitivity tests were performed to verify the robustness of the results. Restricted cubic spline regression was used to explore the possible nonlinear relationship between TMT and OS/PFS.

Results: A total of 344 patients were enrolled in this study. The main analysis showed that TMT was positively correlated with overall survival and progression-free survival. The results of multivariate Cox regression after segmentation according to the optimal cutoff value showed that age ≥ 60 years (HR = 1.47, 95% CI: 1.14-1.90, p = 0.003), diabetes (HR = 1.95, 95% CI: 1.26-3.04, p = 0.003) were the risk factors for death. However, TMT ≥ 8.425 mm (HR = 0.45, 95% CI: 0.36-0.57, p < 0.001), Karnofsky ≥ 70 (HR = 0.76, 95% CI: 0.59-0.97, p < 0.031) were associated with a lower risk of death. Age ≥ 60 years (HR = 1.33, 95% CI: 1.03-1.71, p = 0.028) was a risk factor for recurrence, Karnofsky ≥ 70 (HR = 0.76, 95% CI: 0.59-0.97, p = 0.027), TMT ≥ 8.4 mm (HR = 0.64, 95% CI: 0.50-0.80, p < 0.001), and combination of targeted therapy (HR = 0.65, 95% CI: 0.47-0.90, p = 0.01) reduced recurrence risk.

Conclusion: TMT is an independent predictor of OS and PFS in IDH wild-type GBM patients and can be used to predict prognosis in clinical practice.

Key points: Question Performance status of glioblastoma patients is crucial for treatment decision-making and prognosis assessment; however, there is currently no objective evaluation metric for the Chinese population. Findings Temporal muscle thickness at initial diagnosis is positively correlated with overall survival and progression-free survival in Chinese patients with newly diagnosed IDH wild-type glioblastoma. Clinical relevance Temporal muscle thickness at initial diagnosis is an independent, objective prognostic factor for newly diagnosed IDH wild-type glioblastoma patients in China. It contributes to the formulation of individualized treatment plans and serves as a stratification factor in clinical trials.

颞肌厚度对新诊断IDH野生型胶质母细胞瘤患者预后的预测价值:在中国人群中的评估
目的:本研究旨在探讨颞肌厚度(TMT)在中国新诊断的异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤患者中的预后价值。方法:回顾性收集2019年5月至2023年5月在我中心接受手术治疗和同步放化疗的异柠檬酸脱氢酶野生型基因型胶质母细胞瘤患者的数据。使用多模型和多变量Cox回归来检查与总生存期和无进展生存期相关的因素。进行亚组分析和敏感性试验以验证结果的稳健性。采用限制三次样条回归分析TMT与OS/PFS之间可能存在的非线性关系。结果:共有344例患者入组。主要分析显示TMT与总生存期和无进展生存期呈正相关。根据最佳截断值分割后的多因素Cox回归结果显示,年龄≥60岁(HR = 1.47, 95% CI: 1.14 ~ 1.90, p = 0.003)、糖尿病(HR = 1.95, 95% CI: 1.26 ~ 3.04, p = 0.003)是死亡的危险因素。但TMT≥8.425 mm (HR = 0.45, 95% CI: 0.36-0.57, p)结论:TMT是IDH野生型GBM患者OS和PFS的独立预测因子,可用于临床预测预后。胶质母细胞瘤患者的表现状况对治疗决策和预后评估至关重要;然而,目前还没有针对中国人口的客观评价指标。发现中国新诊断IDH野生型胶质母细胞瘤患者初诊时颞肌厚度与总生存期和无进展生存期呈正相关。在中国,初诊断时颞肌厚度是新诊断IDH野生型胶质母细胞瘤患者独立、客观的预后因素。它有助于制定个体化治疗方案,并在临床试验中作为分层因素。
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来源期刊
European Radiology
European Radiology 医学-核医学
CiteScore
11.60
自引率
8.50%
发文量
874
审稿时长
2-4 weeks
期刊介绍: European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.
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