SEEG guided mapping of primary motor cortex in children with epilepsy

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2025-02-01 DOI:10.1016/j.eplepsyres.2025.107517

Sonali Singh , Karim Mithani , Ayako Ochi , Hiroshi Otsubo , Rohit Sharma , Suvasini Sharma , Lauren Sham , Shelly Weiss , George M. Ibrahim , Elizabeth Donner , Puneet Jain

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引用次数: 0

Abstract

Background

Direct cortical electrical stimulation remains the gold standard for delineation of the primary motor cortex in patients with drug-resistant epilepsy (DRE) undergoing epilepsy surgery evaluation

Objective

This study aimed to explore the efficacy and safety of functional motor mapping through Stereo-EEG (SEEG) electrode contacts in children with DRE at our institute.

Methods

We performed a retrospective analysis of children who underwent SEEG evaluation and functional cortical mapping via bipolar electrical stimulation at our institution between July 2020 and June 2024. Detailed clinical, radiological and neurophysiological variable were extracted; qualitative and quantitative variables were summarized using appropriate descriptive statistics.

Results

A total of 29 patients underwent functional cortical motor mapping via SEEG with the mean age of 12.5 years (standard deviation, 4.1). Stimulation was performed using 50 Hz bipolar electrical stimulation. Succesful motor mapping was reported in 28 patients (96.6 %). The median lowest current threshold for a motor response was 2 mA. The spectrum of motor responses reported included: tonic/dystonic (26), clonic (6), and jerk/jitteriness (1). Afterdischarges were noted in 14 patients (48.3 %) and seizures were seen in 5 patients (17.2 %).

Conclusions

SEEG guided electrical stimulation of motor cortex is feasible and safe for functional cortical mapping in children with epilepsy.

查看原文本刊更多论文

SEEG引导下癫痫患儿初级运动皮层的定位。

背景：对接受癫痫手术的耐药癫痫（DRE）患者，直接皮质电刺激仍然是描述初级运动皮层的金标准。目的：本研究旨在探讨通过立体脑电图（SEEG）电极接触对DRE患儿进行功能性运动定位的有效性和安全性。方法：我们对2020年7月至2024年6月期间在我们机构接受SEEG评估和双极电刺激功能皮质测绘的儿童进行了回顾性分析。提取详细的临床、放射学和神经生理学变量；使用适当的描述性统计对定性和定量变量进行总结。结果：共有29例患者通过SEEG进行了功能性皮质运动映射，平均年龄为12.5岁（标准差为4.1）。采用50 Hz双极电刺激进行刺激。28例患者运动定位成功（96.6% %）。运动反应的最低电流阈值中位数为2 mA。报告的运动反应谱包括：强直/张力障碍（26），阵挛(6)和抽搐/紧张(1)。14例患者（48.3 %）出现后放电，5例患者（17.2 %）出现癫痫发作。结论：SEEG引导下的运动皮质电刺激对癫痫患儿的皮质功能定位是可行且安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.