SEEG guided mapping of primary motor cortex in children with epilepsy

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2025-02-01 DOI:10.1016/j.eplepsyres.2025.107517

Sonali Singh , Karim Mithani , Ayako Ochi , Hiroshi Otsubo , Rohit Sharma , Suvasini Sharma , Lauren Sham , Shelly Weiss , George M. Ibrahim , Elizabeth Donner , Puneet Jain

{"title":"SEEG guided mapping of primary motor cortex in children with epilepsy","authors":"Sonali Singh , Karim Mithani , Ayako Ochi , Hiroshi Otsubo , Rohit Sharma , Suvasini Sharma , Lauren Sham , Shelly Weiss , George M. Ibrahim , Elizabeth Donner , Puneet Jain","doi":"10.1016/j.eplepsyres.2025.107517","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Direct cortical electrical stimulation remains the gold standard for delineation of the primary motor cortex in patients with drug-resistant epilepsy (DRE) undergoing epilepsy surgery evaluation</div></div><div><h3>Objective</h3><div>This study aimed to explore the efficacy and safety of functional motor mapping through Stereo-EEG (SEEG) electrode contacts in children with DRE at our institute.</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of children who underwent SEEG evaluation and functional cortical mapping via bipolar electrical stimulation at our institution between July 2020 and June 2024. Detailed clinical, radiological and neurophysiological variable were extracted; qualitative and quantitative variables were summarized using appropriate descriptive statistics.</div></div><div><h3>Results</h3><div>A total of 29 patients underwent functional cortical motor mapping via SEEG with the mean age of 12.5 years (standard deviation, 4.1). Stimulation was performed using 50 Hz bipolar electrical stimulation. Succesful motor mapping was reported in 28 patients (96.6 %). The median lowest current threshold for a motor response was 2 mA. The spectrum of motor responses reported included: tonic/dystonic (26), clonic (6), and jerk/jitteriness (1). Afterdischarges were noted in 14 patients (48.3 %) and seizures were seen in 5 patients (17.2 %).</div></div><div><h3>Conclusions</h3><div>SEEG guided electrical stimulation of motor cortex is feasible and safe for functional cortical mapping in children with epilepsy.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"210 ","pages":"Article 107517"},"PeriodicalIF":2.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsy Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S092012112500018X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Direct cortical electrical stimulation remains the gold standard for delineation of the primary motor cortex in patients with drug-resistant epilepsy (DRE) undergoing epilepsy surgery evaluation

Objective

This study aimed to explore the efficacy and safety of functional motor mapping through Stereo-EEG (SEEG) electrode contacts in children with DRE at our institute.

Methods

We performed a retrospective analysis of children who underwent SEEG evaluation and functional cortical mapping via bipolar electrical stimulation at our institution between July 2020 and June 2024. Detailed clinical, radiological and neurophysiological variable were extracted; qualitative and quantitative variables were summarized using appropriate descriptive statistics.

Results

A total of 29 patients underwent functional cortical motor mapping via SEEG with the mean age of 12.5 years (standard deviation, 4.1). Stimulation was performed using 50 Hz bipolar electrical stimulation. Succesful motor mapping was reported in 28 patients (96.6 %). The median lowest current threshold for a motor response was 2 mA. The spectrum of motor responses reported included: tonic/dystonic (26), clonic (6), and jerk/jitteriness (1). Afterdischarges were noted in 14 patients (48.3 %) and seizures were seen in 5 patients (17.2 %).

Conclusions

SEEG guided electrical stimulation of motor cortex is feasible and safe for functional cortical mapping in children with epilepsy.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.