Injection of Different Concentrations of Recombinant Humanized Type III Collagen Into the Dermis Promotes Type III and Type I Collagen Deposition as Well as Angiogenesis: An In Vivo Study.

IF 2.5 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2025-01-31 DOI:10.1097/DSS.0000000000004553

Haibo Xiang, Yimou Sun, Yujie Chen, Guanhuier Wang, Hongbin Xie

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引用次数: 0

Abstract

Background: Type III recombinant humanized collagen (rhCol III) has a promising future in cosmetic applications.

Objective: To investigate the histological changes associated with injection of different concentrations of Type III rhCol III into the dermis.

Materials and methods: Twenty mice were divided into a control, low-dose (LD) group, and high-dose (HD) group. The animals were euthanized 1, 2, 3, and 4 weeks after the injection.

Results: Injections of rhCol III induced an increase in collagen formation in a concentration-dependent manner. Type I collagen (Col I) was upregulated in both HD and LD groups to varying extents, often similar to that of Col III. Fibroblast proliferation plays an important role in the deposition of Col I and Col III. Injections of rhCol III promoted angiogenesis at later stages, regardless of concentration dependency.

Conclusion: Intradermal injections of rhCol III can promote fibroblast proliferation, enhancing the deposition of both Col I and Col III, and stimulating angiogenesis. Further studies are required to elucidate the mechanisms.

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.