The prevalence of autoimmune thyroiditis is not increased in women with polycystic ovary syndrome after adjustment for family predisposition.

IF 3.7 3区医学 Q2 Medicine

Endocrine Pub Date : 2025-01-30 DOI:10.1007/s12020-025-04181-3

Andromachi Vryonidou, Maria Mizamtsidi, Eleni Palioura, Nikolaos Kalogeris, Evangeline Vassilatou, Dimitrios Ioannidis, Vicky Loi, Stavroula A Paschou

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Abstract

Purpose: Several studies suggest a linkage between PCOS and autoimmunity with a high frequency of chronic autoimmune thyroiditis (AIT) reported in PCOS patients, however, this subject remains controversial. The aim of this study was to investigate the prevalence of AIT in PCOS women and identify parameters that would serve as independent predictors of AIT.

Methods: Two hundred fifty seven (257) PCOS patients according to the NIH criteria and one hundred forty three (143) controls, women with normal menstrual cycles and without clinical or biochemical hyperandrogenism, were recruited for the study. Anthropometric characteristics and a complete family history for AIT were recorded. Thyroid hormones, antithyroid antibodies, androgen, glucose and insulin levels were measured. Thyroid gland structure was evaluated by ultrasound scan.

Results: Patients and controls did not differ in age, BMI as well as genetic predisposition for AIT (p > 0.05). Women with PCOS presented higher levels of androgens and HOMA-IR index, as expected. AIT prevalence did not differ between women with PCOS and controls (4.8 vs 9.3%, p = 0.13). However, the subgroup of PCOS patients with AIT presented a significantly stronger predisposition for AIT (33.3 vs 4.7%, p = 0.004) compared to patients without AIT. In a multivariate regression model, a positive family history of AIT was proved to be the strongest independent predictor of AIT in the PCOS group (OR 7.06, 95% CI 1.04-47.79, R² = 0.39).

Conclusion: The prevalence of AIT in the PCOS patients does not differ from the general population when family predisposition to AIT is taken into account.

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自身免疫性甲状腺炎的患病率在多囊卵巢综合征的妇女调整家庭易感性后没有增加。

目的：几项研究表明多囊卵巢综合征和自身免疫之间存在联系，多囊卵巢综合征患者中慢性自身免疫性甲状腺炎（AIT）的发生率很高，然而，这一主题仍存在争议。本研究的目的是调查PCOS女性AIT的患病率，并确定可作为AIT独立预测因子的参数。方法：选取符合NIH标准的257例PCOS患者和143例月经周期正常、无临床或生化高雄激素症的女性作为对照。记录了AIT的人体测量特征和完整的家族史。测量甲状腺激素、抗甲状腺抗体、雄激素、葡萄糖和胰岛素水平。超声检查甲状腺结构。结果：患者和对照组在年龄、BMI和AIT遗传易感性方面无差异（p < 0.05）。与预期一样，多囊卵巢综合征的女性表现出更高水平的雄激素和HOMA-IR指数。AIT患病率在PCOS女性和对照组之间没有差异（4.8% vs 9.3%, p = 0.13）。然而，患有AIT的PCOS患者亚组与没有AIT的患者相比，AIT的易发性明显更强（33.3% vs 4.7%, p = 0.004）。在多元回归模型中，阳性AIT家族史被证明是PCOS组AIT的最强独立预测因子（OR 7.06, 95% CI 1.04-47.79, R2 = 0.39）。结论：在考虑家族易感因素的情况下，PCOS患者的AIT患病率与一般人群无明显差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.