Diagnostic utility of next-generation sequencing in neurological infections: Two cases in point

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-01-23 DOI:10.1016/j.diagmicrobio.2025.116713

Ravi Teja Kandikuppa , Vidya Krishna , Nandini Sethuraman , Anuradha Sridhar , Srinivasan Paramasivam

引用次数: 0

Abstract

We report the successful management of two cases of brain abscess and subdural empyema caused by Fusobacterium nucleatum and Streptococcus intermedius diagnosed using 16S ribosomal RNA (rRNA) sequencing where microbiological culture showed no growth. This report elucidates the utility of next-generation sequencing (NGS) in determining the microbial etiology and guiding appropriate antimicrobial treatment in life-threatening neurological infections.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.