Associations of dietary factors with amyotrophic lateral sclerosis: A Mendelian randomization study

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-01-27 DOI:10.1016/j.clnesp.2025.01.042

Fei Xu , Hongwei Liu , Zhaoxu Yin, Xiaolian Xing, Xuan Chen

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引用次数: 0

Abstract

Background

An inconsistent yet notable relationship between dietary habits and the risk of amyotrophic lateral sclerosis (ALS) has been previously established, with the causative nature of this relationship remaining uncertain. This study aims to explore the causal connections at a genetic level.

Methods

A two-sample Mendelian Randomization (MR) based analysis was conducted utilizing a comprehensive, publicly assessable Genome-wide association study (GWAS) database. Fourteen dietary variables were examined as potential exposure factors, and the ALS outcome data was statistically analyzed. The inverse-variance weighted (IVW) approach was used as the primary analytical method, supplemented by sensitivity analyses to assess the reliability of our findings.

Results

Our analysis identified significant protective effects against ALS from increased intake of water (fixed-effects IVW: OR = 0.700, 95 % CI: 0.524–0.935, P = 0.016), fresh fruit (random-effects IVW: OR = 0.561, 95 % CI: 0.361–0.871, P = 0.010), and cooked vegetable (fixed-effects IVW: OR = 0.200, 95 % CI: 0.090–0.445, P = 0.000). No significant associations were found for the other 11 dietary factors examined.

Conclusion

The study highlights the protective association of cooked vegetables and fresh fruit intake with ALS risk reduction. Additionally, an intriguing association between water intake and ALS was observed, warranting further investigation to elucidate the underlying mechanisms.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.