No Association Found Between Uric Acid Levels and Peripheral Vertigo Disorders: Results From a Two-Sample Mendelian Randomization Study

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-01-30 DOI:10.1111/coa.14288

Shihan Liu, Yiyi Lin, Lingli Zhang, Wenlong Luo

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引用次数: 0

Abstract

Background

The association between serum uric acid levels and peripheral vertigo diseases, namely Benign Paroxysmal Positional Vertigo (BPPV), Meniere's Disease (MD), and Vestibular Neuritis (VN), remains a subject of controversy. This study utilises the Mendelian Randomization (MR) approach to investigate the potential link between uric acid levels and these peripheral vertigo diseases, with the goal of informing preventative measures and early intervention strategies.

Methods

Datasets pertaining to uric acid levels (sample size = 343 836) and BPPV (ncase = 3834, ncontrol = 209 582), MD (ncase = 1511, ncontrol = 209 582), and VN (ncase = 1224, ncontrol = 209 582) were selected from Genome-Wide Association Studies (GWAS). Two-sample MR was employed to analyse the correlation between the exposure (uric acid levels) and outcomes (BPPV, MD, VN). The MR analysis methods encompassed Inverse Variance Weighting (IVW), MR-Egger, Simple Mode, Weighted Mode, and Weighted Median methods. The results derived from the IVW analysis were considered as the primary analytical outcomes.

Result

The findings indicated no significant correlation between uric acid levels and BPPV (IVW: OR = 1.152, 95% CI: 0.971–1.367, p = 0.103), MD (IVW: OR = 1.010, 95% CI: 0.757–1.348, p = 0.943), and VN (IVW: OR = 1.005, 95% CI: 0.744–1.358, p = 0.969).

Conclusion

This study employed a two-sample Mendelian randomization approach to conduct an in-depth analysis of the relationship between serum uric acid levels and peripheral vestibular diseases (BPPV, MD, and VN). Our findings indicate that no significant association was found between serum uric acid levels and these diseases. The results of the study do not support the hypothesis that uric acid is an independent risk factor for these conditions.

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尿酸水平与周围性眩晕疾病之间未发现关联：来自两样本孟德尔随机研究的结果。

背景：血清尿酸水平与周围性眩晕疾病，即良性阵发性位置性眩晕（BPPV）、梅尼埃病（MD）和前庭神经炎（VN）之间的关系仍然是一个有争议的主题。本研究利用孟德尔随机化（MR）方法调查尿酸水平与这些周围性眩晕疾病之间的潜在联系，目的是为预防措施和早期干预策略提供信息。方法：从全基因组关联研究（GWAS）中选择与尿酸水平（样本量= 343 836）、BPPV （ncase = 3834, ncontrol = 209 582）、MD （ncase = 1511, ncontrol = 209 582）和VN （ncase = 1224, ncontrol = 209 582）相关的数据集。采用双样本磁共振分析暴露（尿酸水平）与结果（BPPV、MD、VN）之间的相关性。磁共振分析方法包括方差反加权法（IVW）、MR- egger法、简单模式法、加权模式法和加权中位数法。IVW分析的结果被认为是主要的分析结果。结果：尿酸水平与BPPV （IVW: OR = 1.152, 95% CI: 0.971 ~ 1.367, p = 0.103）、MD （IVW: OR = 1.010, 95% CI: 0.757 ~ 1.348, p = 0.943）、VN （IVW: OR = 1.005, 95% CI: 0.744 ~ 1.358, p = 0.969）无显著相关性。结论：本研究采用双样本孟德尔随机化方法，深入分析血清尿酸水平与周围前庭疾病（BPPV、MD和VN）之间的关系。我们的研究结果表明，血清尿酸水平与这些疾病之间没有明显的关联。研究结果不支持尿酸是这些疾病的独立危险因素的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.