Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson’s disease

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-01-27 DOI:10.1016/j.clinph.2025.01.005

Arnaldo Fim Neto , Fabio Godinho , Luiz Ricardo Trajano da Silva , Julia Baldi de Luccas , André Kazuo Takahata , Eberval Gadelha Figueiredo , Carlos Gilberto Carlotti Junior , Maria Sheila Guimarães Rocha , Diogo Coutinho Soriano

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引用次数: 0

Abstract

Introduction: Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson’s disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP). Methods: The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG). Results: FOG patients presented enhanced alpha bandpower (FOG vs. n-FOG: 0.331 ± 0.087 vs. 0.248 ± 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG vs. n-FOG: 0.610 ± 0.068 vs. 0.524 ± 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = −0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index. Conclusion: These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms. Significance: The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.