Roots and early routes of neuroendocrinology.

IF 3.2 3区 生物学 Q3 CELL BIOLOGY
Cell and Tissue Research Pub Date : 2025-05-01 Epub Date: 2025-01-30 DOI:10.1007/s00441-024-03928-0
Esteban M Rodríguez, Montserrat Guerra, Juan Luis Blázquez
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Abstract

Carl C. Speidel (1919) and Ernst Scharrer (1928) were privileged witnesses of the encounter between neurons and hormones, a biological phenomenon that had been occurring in nature during millions of years of evolution, as Berta Scharrer started to unfold since 1935 on. The story of neurosecretion is intimately associated to that of the hypothalamus, such a "marvellous region", as Wolfgang Bargmann (1975) called it. This story started more than two millennia ago. We have made an effort to trace the roots of the discoveries that gave rise to a medical discipline, neuroendocrinology. Our trip to the roots covers a period from the fourth century BC, when an extraordinary Medical School was founded in Alexandria, and extends into the late 1970s of the twentieth century, when neuroendocrine research had started to grow exponentially. An effort has been made to track back the origin of each piece of knowledge that was constructing, brick upon brick, the building of this new medical science, hoping that it would help neuroendocrinologists of the new era to find their own roots, to meet their ancestors. Tracking the roots of a particular phenomenon provides the opportunity to have an overview of the whole phenomenon, allowing comprehension rather than merely knowledge. An important purpose pursued throughout this article was to pay a tribute to all those who, in the early days, contributed to the brain-endocrine encounter. We have tried our best to bring back the achievements of most of them.

神经内分泌学的根源和早期途径。
Carl C. Speidel(1919)和Ernst Scharrer(1928)有幸见证了神经元和激素之间的相遇,这是一种生物现象,在自然界数百万年的进化过程中一直在发生,正如Berta Scharrer从1935年开始展开的那样。神经分泌的故事与下丘脑的故事密切相关,正如沃尔夫冈•巴格曼(Wolfgang Bargmann, 1975)所说的那样,下丘脑是一个“神奇的区域”。这个故事始于两千多年前。我们一直在努力追溯这些发现的根源,这些发现产生了一门医学学科——神经内分泌学。我们的寻根之旅从公元前4世纪开始,当时在亚历山大建立了一所非凡的医学院,一直延伸到20世纪70年代末,当时神经内分泌研究开始呈指数级增长。人们一直在努力追溯每一项知识的起源,这些知识一砖一瓦地构建着这门新的医学科学,希望它能帮助新时代的神经内分泌学家找到自己的根,去见他们的祖先。追踪一个特定现象的根源提供了对整个现象有一个概览的机会,允许理解而不仅仅是知识。贯穿这篇文章的一个重要目的是向所有在早期为脑内分泌研究做出贡献的人致敬。我们已经尽了最大的努力把他们中的大多数人的成就带回来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell and Tissue Research
Cell and Tissue Research 生物-细胞生物学
CiteScore
7.00
自引率
2.80%
发文量
142
审稿时长
1 months
期刊介绍: The journal publishes regular articles and reviews in the areas of molecular, cell, and supracellular biology. In particular, the journal intends to provide a forum for publishing data that analyze the supracellular, integrative actions of gene products and their impact on the formation of tissue structure and function. Submission of papers with an emphasis on structure-function relationships as revealed by recombinant molecular technologies is especially encouraged. Areas of research with a long-standing tradition of publishing in Cell & Tissue Research include: - neurobiology - neuroendocrinology - endocrinology - reproductive biology - skeletal and immune systems - development - stem cells - muscle biology.
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