Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2025-01-29 DOI:10.1177/19476035241313047

Veronika Janacova, Pavol Szomolanyi, Diana Sitarcikova, Alexandra Kirner, Siegfried Trattnig, Vladimir Juras

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引用次数: 0

Abstract

Objective: The objective of this study was to assess the maturation of matrix-associated autologous chondrocyte transplantation (MACT) grafts up to 2 years after the surgery using gray-level co-occurrence matrix (GLCM) texture analysis of quantitative T₂ maps, compare the results with the microfracturing technique (MFX) control group, and relate these results to the morphological MOCART 2.0 score.

Design: A subcohort of 37 patients from prospective, multi-center study underwent examination on a 3T MR scanner, including a T₂ mapping sequence at 3, 12, and 24 months after surgery. Changes between the time-points in the mean T₂ values and 20 GLCM features extracted from T₂ maps were assessed in repair tissue, tissue adjacent to the repair site, and the reference cartilage for both procedures.

Results: Significant correlations were found between the MOCART 2.0 and GLCM features for both surgical procedures. There were no significant differences between MACT and MFX. We identified significant intra-group changes in T₂ and autocorrelation (3M-12M: P = 0.002; 3M-24M: P = 0.004), dissimilarity (3M-24M: P = 0.01), homogeneity (3M-24M: P = 0.013), and correlation (3M-24M: P = 0.036), sum average (3M-12M: P = 0.001; 3M-24M: P = 0.002), and information measure (3M-24M: P < 0.001) in the MACT repair tissue. MACT models revealed differences in GLCM between all combinations of ROI types at almost all time-points. In the case of MFX, the significant differences were mainly between repair and reference tissue at 12 months.

Conclusion: Texture analysis provides a useful extension to T₂ mapping. Texture features are correlated to the morphological outcome and reveal differences in the process of maturation between MACT and MFX.

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软骨修复组织成熟的纹理分析：两种软骨修复方法的比较及与MOCART 2.0的相关性。

目的：本研究的目的是通过定量T2图谱的灰度共生基质（GLCM）纹理分析来评估基质相关自体软骨细胞移植（MACT）移植术后2年的成熟度，并将结果与微压裂技术（MFX）对照组进行比较，并将这些结果与形态学MOCART 2.0评分相关联。设计：来自前瞻性多中心研究的37例患者的亚队列接受了3T MR扫描仪检查，包括术后3、12和24个月的T2定位序列。在修复组织、修复部位附近组织和两种手术的参考软骨中，评估平均T2值和从T2图中提取的20个GLCM特征的时间点之间的变化。结果：两种手术方式的MOCART 2.0与GLCM特征之间存在显著相关性。MACT与MFX之间无显著差异。我们发现T2和自相关性组内显著变化(3M-12M: P = 0.002；3M-24M: P = 0.004)、差异性（3M-24M: P = 0.01）、同质性（3M-24M: P = 0.013）、相关性（3M-24M: P = 0.036）、总平均（3M-12M: P = 0.001）；3M-24M: P = 0.002)， MACT修复组织的信息测量（3M-24M: P < 0.001）。MACT模型揭示了几乎所有时间点所有ROI类型组合之间GLCM的差异。在MFX的情况下，12个月时的显著差异主要在修复组织和参考组织之间。结论：纹理分析为T2映射提供了有益的扩展。纹理特征与形态学结果相关，揭示了MACT和MFX在成熟过程中的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.