Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning.

IF 5.7 2区 生物学 Q1 BIOLOGY
Yiqin Yang, Mei Dong
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引用次数: 0

Abstract

Background: Carotid atherosclerotic plaque is the primary cause of cardiovascular and cerebrovascular diseases. It is closely related to oxidative stress and immune inflammation. This bioinformatic study was conducted to identify key oxidative stress-related genes and key immune cell infiltration involved in the formation, progression, and stabilization of plaques and investigate the relationship between them.

Results: We show that the up-regulation of oxidative stress-related genes such as IDH1 and CD36 in resident-like macrophages and foam macrophages play a key role in the formation and progression of carotid atherosclerotic plaques.

Conclusions: We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. It introduced novel insights into the mechanisms underlying carotid atherosclerosis formation and plaque progression and may assist in identifying potential therapeutic targets for their treatment.

探索氧化应激在颈动脉粥样硬化中的作用:来自转录组学数据和单细胞测序结合机器学习的见解。
背景:颈动脉粥样硬化斑块是心脑血管疾病的主要病因。它与氧化应激和免疫炎症密切相关。本生物信息学研究旨在确定参与斑块形成、发展和稳定的关键氧化应激相关基因和关键免疫细胞浸润,并探讨它们之间的关系。结果:我们发现,在巨噬细胞和泡沫巨噬细胞中,氧化应激相关基因如IDH1和CD36的上调在颈动脉粥样硬化斑块的形成和进展中起关键作用。结论:我们通过结合预测模型和单细胞数据分析,讨论了氧化应激和免疫炎症在斑块形成、进展和稳定中的作用。它对颈动脉粥样硬化形成和斑块进展的机制提出了新的见解,并可能有助于确定其治疗的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology Direct
Biology Direct 生物-生物学
CiteScore
6.40
自引率
10.90%
发文量
32
审稿时长
7 months
期刊介绍: Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.
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