Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank.

IF 3.9 3区 医学 Q1 PSYCHIATRY
BJPsych Open Pub Date : 2025-01-31 DOI:10.1192/bjo.2024.845
Jaegyun Jung, Sangyeon Lee, Jeong Ho Lee, Doheon Lee
{"title":"Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank.","authors":"Jaegyun Jung, Sangyeon Lee, Jeong Ho Lee, Doheon Lee","doi":"10.1192/bjo.2024.845","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.</p><p><strong>Aims: </strong>To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.</p><p><strong>Method: </strong>We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour.</p><p><strong>Results: </strong>A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08-0.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour.</p><p><strong>Conclusions: </strong>A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 1","pages":"e27"},"PeriodicalIF":3.9000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822987/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BJPsych Open","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1192/bjo.2024.845","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.

Aims: To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.

Method: We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour.

Results: A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08-0.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour.

Conclusions: A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients.

不同基因型抑郁症患者的身体活动和自残行为之间的联系:来自英国生物银行的研究结果。
背景:体育活动被广泛用于缓解抑郁症状的非药物干预。然而,几乎没有证据支持它们在降低抑郁症患者自残风险方面的基因型特异性有效性。目的:评估体力活动与自残行为之间的关系,并确定跨基因型的体力活动推荐水平。方法:建立双向分析模型,研究UK Biobank的基因型特异性有效性。采用层次聚类对抑郁表型队列进行遗传分层后,建立多变量logistic回归模型和Cox比例风险模型,探讨运动与自残行为风险之间的关系。结果:共纳入抑郁表型受试者28 923人。在回顾性队列分析中,中度和高度运动组的自残行为风险较低。在随后的前瞻性队列分析中,在一个遗传集群中,低强度体育活动与自残行为导致的住院风险较低相关(调整后的风险比为0.28 [95% CI, 0.08-0.96]),该遗传集群由三个遗传变异rs1432639、rs4543289和rs11209948区分开来。遵循指南水平的中高强度体育活动与自残行为的风险没有显著关系。结论:基因型特异性剂量的轻强度体力活动可使抑郁症患者的自残风险降低约四分之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BJPsych Open
BJPsych Open Medicine-Psychiatry and Mental Health
CiteScore
6.30
自引率
3.70%
发文量
610
审稿时长
16 weeks
期刊介绍: Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信