{"title":"Development and Functions of MAIT Cells.","authors":"Marion Salou, Rafael A Paiva, Olivier Lantz","doi":"10.1146/annurev-immunol-082323-025943","DOIUrl":null,"url":null,"abstract":"<p><p>Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions. In this article, we discuss the evolutionary conservation of MAIT cells and describe their original developmental process. MAIT cells exert a wide variety of effector functions, from killing infected cells and promoting inflammation to repairing tissues. We provide insights into these functions and discuss how they result from the context of stimulation encountered by MAIT cells in different tissues and pathological settings. We describe how MAIT cell numbers and features are modified in disease states, focusing mainly on in vivo models. Lastly, we discuss emerging strategies to manipulate MAIT cells for therapeutic purposes.</p>","PeriodicalId":8271,"journal":{"name":"Annual review of immunology","volume":" ","pages":"253-283"},"PeriodicalIF":26.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-immunol-082323-025943","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/29 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that recognize microbial metabolites. They are abundant in humans and conserved during mammalian evolution, which suggests that they have important nonredundant functions. In this article, we discuss the evolutionary conservation of MAIT cells and describe their original developmental process. MAIT cells exert a wide variety of effector functions, from killing infected cells and promoting inflammation to repairing tissues. We provide insights into these functions and discuss how they result from the context of stimulation encountered by MAIT cells in different tissues and pathological settings. We describe how MAIT cell numbers and features are modified in disease states, focusing mainly on in vivo models. Lastly, we discuss emerging strategies to manipulate MAIT cells for therapeutic purposes.
mucal -associated invariant T （MAIT）细胞是进化上保守的T细胞，可识别微生物代谢物。它们在人类中大量存在，并在哺乳动物进化过程中保存下来，这表明它们具有重要的非冗余功能。在这篇文章中，我们讨论了MAIT细胞的进化保护，并描述了它们最初的发育过程。MAIT细胞发挥各种各样的效应功能，从杀死感染细胞和促进炎症到修复组织。我们提供了对这些功能的见解，并讨论了它们是如何从不同组织和病理环境中MAIT细胞所遇到的刺激中产生的。我们描述了MAIT细胞的数量和特征在疾病状态下是如何改变的，主要集中在体内模型上。最后，我们讨论了用于治疗目的的操纵MAIT细胞的新策略。
期刊介绍：
The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.
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