Willingness to Use Long-Acting Injectable Pre-Exposure Prophylaxis among Adolescent Girls and Young Women in Kampala, Uganda

IF 2.7 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

AIDS and Behavior Pub Date : 2025-01-30 DOI:10.1007/s10461-025-04616-y

Jane Frances Lunkuse, Charles Lwanga, Felix Wamono, Vincent Muturi-Kioi, Matt Price, Yunia Mayanja

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引用次数: 0

Abstract

Pre-exposure prophylaxis (PrEP) has proven to be a powerful tool in preventing HIV infection. There is limited information about the factors associated with willingness to use different PrEP modalities among adolescent girls and young women (AGYW) in Africa. We assessed willingness to use long-acting injectable PrEP (LAI-PrEP) among 14-24-year-old AGYW at high risk of HIV in Uganda, and associated factors determined using multivariable complementary log-log regression. Of the 285 participants, 69.8% of participants showed willingness to use LAI-PrEP despite only 3.9% having knowledge about it before enrolment. Report of recent transactional sex was high (92.6%). Participants that were divorced/separated (aOR = 1.74, 95% CI 1.03–2.92) and those with multiple sexual partners (aOR = 2.11, 95% CI 1.46–3.06) compared to those with one partner were more likely to be willing to use LAI-PrEP while those that were screened as heavy episodic drinkers (consuming 6 or more drinks on an occasion as per the AUDIT tool) were less likely to be willing to use LAI-PrEP (aOR = 0.61, 95% CI 0.42–0.87). LAI PrEP has shown efficacy in clinical trials; the product is approved for use by the Government of Uganda (MoH) and should be expedited for use by AGYW engaged in paid sex and those with multiple sexual partnerships. As it becomes available, we recommend PrEP education and counseling to increase awareness of LAI PrEP as an alternative HIV prevention method.

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乌干达坎帕拉的少女和年轻妇女使用长效注射暴露前预防的意愿。

暴露前预防（PrEP）已被证明是预防艾滋病毒感染的有力工具。关于非洲少女和年轻妇女（AGYW）使用不同PrEP方式的意愿相关因素的信息有限。我们评估了乌干达14-24岁HIV高风险AGYW中使用长效注射PrEP （LAI-PrEP）的意愿，并使用多变量互补对数-对数回归确定了相关因素。在285名参与者中，69.8%的参与者表示愿意使用LAI-PrEP，尽管只有3.9%的参与者在注册前了解它。最近的性交易报告很高（92.6%）。与只有一个伴侣的参与者相比，离婚/分居的参与者（aOR = 1.74, 95% CI 1.03-2.92）和有多个性伴侣的参与者（aOR = 2.11, 95% CI 1.46-3.06）更愿意使用ai - prep，而那些被筛选为重度间歇性饮酒者（根据审计工具每次饮用6杯或更多饮料）不太愿意使用ai - prep （aOR = 0.61, 95% CI 0.42-0.87）。LAI PrEP已在临床试验中显示出疗效；该产品已被乌干达政府（MoH）批准使用，并应加速供从事有偿性行为的AGYW和有多性伙伴关系的AGYW使用。当它变得可用时，我们建议PrEP教育和咨询，以提高人们对LAI PrEP作为一种替代艾滋病毒预防方法的认识。

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来源期刊

AIDS and Behavior Multiple-

CiteScore

6.60

自引率

13.60%

发文量

382

期刊介绍： AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76