Pre-exposure Prophylaxis (PrEP) Awareness and Engagement Among MSM at High Risk of HIV Infection in China: A Multi-City Cross-Sectional Survey

IF 2.7 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Jun Du, Sainan Wang, Hongbo Zhang, Tao Liu, Shufang Sun, Cui Yang, Nickolas Zaller, Zhen Dai, Haipeng Zha, Yanqiu Zhao, Yue Zhao, Xuejiao Hu, Han Yan, Pan Gao, Jun Wang, Yehuan Sun, Zhihua Zhang, Operario Don
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Abstract

This study aimed to explore the awareness, willingness, and engagement with pre-exposure prophylaxis (PrEP) among high-risk Chinese men who have sex with men (MSM) and to investigate the factors influencing its use. A cross-sectional survey of 1800 HIV-negative MSM was conducted in Chengdu, Suzhou, and Wuhan between June 2022 and February 2023 through in-person and online recruitment methods. Univariate and multivariate logistic regression analyses were used to identify predictors of PrEP use. Bayesian network models were constructed using the bnlearn package in R 4.1.2, and inference was conducted using Netica software. Among the 1800 participants, 1467 had ever heard of PrEP, 696 were aware of its target population, and 195 had taken PrEP in the past 6 months. PrEP use was higher among individuals reporting multiple male sex partners, illicit substance use, alcohol use, HIV testing, PEP use, and sexual partners who had used PrEP. Conversely, having a female sexual partner was a barrier to PrEP use. Bayesian network modeling unveiled factors directly and indirectly impacting PrEP use. Variables like PrEP use of sexual partners, PEP use, alcohol use, HIV testing, and WeChat-based HIV knowledge platforms exhibited direct effects. Indirect effects included having a female sexual partner, number of male sexual partners, and illicit substance use. Despite high awareness, the usage of PrEP remains low among MSM. Encouraging social agencies to leverage social media platforms to provide comprehensive HIV care services, especially to meet the PrEP needs of MSM.

中国HIV感染高危人群的暴露前预防(PrEP)意识和参与:一项多城市横断面调查
本研究旨在探讨中国高危男男性行为者(MSM)对暴露前预防(PrEP)的认知、意愿和参与情况,并探讨其使用的影响因素。在2022年6月至2023年2月期间,通过面对面和在线招募的方式对成都、苏州和武汉的1800名hiv阴性男男性行为者进行了横断面调查。采用单因素和多因素logistic回归分析确定PrEP使用的预测因素。使用r4.1.2中的bnlearn包构建贝叶斯网络模型,使用Netica软件进行推理。在1800名参与者中,1467人听说过PrEP, 696人知道其目标人群,195人在过去6个月内服用过PrEP。在报告有多名男性性伴侣、非法药物使用、酒精使用、艾滋病毒检测、PEP使用和使用过PrEP的性伴侣的人群中,PrEP使用率较高。相反,有女性性伴侣是使用PrEP的障碍。贝叶斯网络模型揭示了直接和间接影响PrEP使用的因素。性伴侣的PrEP使用、PEP使用、酒精使用、艾滋病毒检测和基于微信的艾滋病毒知识平台等变量表现出直接影响。间接影响包括有女性性伴侣、男性性伴侣数量和非法药物使用。尽管人们对此有很高的认识,但男男性接触者中PrEP的使用率仍然很低。鼓励社会机构利用社交媒体平台提供全面的艾滋病毒护理服务,特别是满足男同性恋者的PrEP需求。
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来源期刊
AIDS and Behavior
AIDS and Behavior Multiple-
CiteScore
6.60
自引率
13.60%
发文量
382
期刊介绍: AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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