Nanomaterials and clinical SERS technology: broad applications in disease diagnosis.

Ifeanyichukwu Michael Onyemaobi, Yujiao Xie, Jiahao Zhang, Lei Xu, Lingchao Xiang, Jie Lin, Aiguo Wu
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引用次数: 0

Abstract

The critical need for rapid cancer diagnosis and related illnesses is growing alongside the current healthcare challenges, unfavorable prognosis, and constraints in diagnostic timing. As a result, emphasis on surface-enhanced Raman spectroscopy (SERS) diagnostic methods, including both label-free and labelled approaches, holds significant promise in fields such as analytical chemistry, biomedical science, and physics, due to the user-friendly nature of SERS. Over time, the SERS detection sensitivity and specificity with nanostructured materials for SERS applications (NMs-SERS) in different media have been remarkable. An investigation into electronic dynamics and interactions has revealed a seemingly fair result regarding the complementary effects of electromagnetic (EM) and chemical enhancements (CM), underscoring the operational principles of SERS. Nevertheless, the focus on translational SERS applications, especially beyond preliminary proof-of-concept research, remains limited. This review focuses on the advancements made in clinical SERS diagnostics and the essential role of NMs-SERS, ranging from plasmonic to non-plasmonic materials and other related advancements. Furthermore, it outlines the significant achievements of biomedical SERS in tumor diagnosis, particularly in identifying circulating tumor cells (CTCs), alongside a clear focus on NMs-SERS characteristics such as surface charge, shape, size, detection sensitivity, specificity, signal reproducibility, and recyclability. Finally, it underscores the use of microfluidic chips within the labelled SERS strategy for isolating CTCs, the concept of Ramanomics, and the integration of artificial intelligence (AI) to strengthen SERS data analysis. We hope that this review will help guide and expedite the potential for precise SERS diagnosis of key chronic diseases.

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来源期刊
Journal of materials chemistry. B
Journal of materials chemistry. B 化学科学, 工程与材料, 生命科学, 分析化学, 高分子组装与超分子结构, 高分子科学, 免疫生物学, 免疫学, 生化分析及生物传感, 组织工程学, 生物力学与组织工程学, 资源循环科学, 冶金与矿业, 生物医用高分子材料, 有机高分子材料, 金属材料的制备科学与跨学科应用基础, 金属材料, 样品前处理方法与技术, 有机分子功能材料化学, 有机化学
CiteScore
12.00
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0
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1 months
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