Photic drive response in people with epilepsy: Exploring the interaction with background alpha rhythm

IF 1.5 4区心理学 Q4 NEUROSCIENCES

Vision Research Pub Date : 2025-01-27 DOI:10.1016/j.visres.2025.108548

Eman N. Ali , Christian J. Lueck , Kate L. Martin , Angela Borbelj , Ted Maddess

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引用次数: 0

Abstract

Photic drive responses (PDRs) are used to explore cortical hyperexcitability. We quantified PDRs and interactions with the alpha rhythm in people with epilepsy (PwE). Fifteen PwE (mean age ± SD 47.3 ± 4.6 years; 8 males), and 15 control subjects (mean age 52.7 ± 4.6 years; 9 males) underwent EEG with modified intermittent photic stimulation (IPS). The modification allowed so-called alpha-band gain to be measured. None of the PwE had demonstrated photosensitivity. The modified IPS method alternated eyes-open and eyes–closed conditions with and without IPS. The alpha-band gain appeared as N-fold changes in PDR when IPS (or its harmonics) and the alpha-bands overlapped. An epileptic attack within 1 month of testing significantly increased alpha-band gain by 1.36×. Generalised epilepsy (but not focal epilepsy) significantly decreased alpha-band gain y 0.79×. Each decade of age beyond the mean age significantly increased alpha-band gain by 1.09×. Similar significant interactions were seen between alpha and the second harmonic of IPS driving frequencies that matched alpha frequencies, i.e. for recent attack and, generalized epilepsy. The interactions thus appeared to be occurring between cortical IPS outputs and the alpha generator. These changes were most evident at electrodes O1 and O2. Investigating alpha-band gain using modified IPS offers a way to quantify cortical hyperexcitability in epilepsy and other diseases. It also provides new information about alpha and so too predictive coding, which appears to be at least partly governed by alpha.

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来源期刊

Vision Research 医学-神经科学

CiteScore

3.70

自引率

16.70%

发文量

111

审稿时长

66 days

期刊介绍： Vision Research is a journal devoted to the functional aspects of human, vertebrate and invertebrate vision and publishes experimental and observational studies, reviews, and theoretical and computational analyses. Vision Research also publishes clinical studies relevant to normal visual function and basic research relevant to visual dysfunction or its clinical investigation. Functional aspects of vision is interpreted broadly, ranging from molecular and cellular function to perception and behavior. Detailed descriptions are encouraged but enough introductory background should be included for non-specialists. Theoretical and computational papers should give a sense of order to the facts or point to new verifiable observations. Papers dealing with questions in the history of vision science should stress the development of ideas in the field.