Preliminary study of the influence of maternal and neonatal NOS3 (rs1799983), IL1B (rs1143634) genes variants and their intergenic interaction on the development of hypoxic-ischemic encephalopathy in newborns in the context of treatment planning.

Q4 Medicine

Wiadomosci lekarskie Pub Date : 2024-01-01 DOI:10.36740/WLek/197108

Yuliia Cherniavska, Alina Davydenko, Valerii Pokhylko, Liliia Fishchuk, Zoia Rossokha

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引用次数: 0

Abstract

Objective: Aim: To determine the influence of maternal and neonatal variants of the eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) genes and their intergenic interactions on the development of HIE in newborns.

Patients and methods: Materials and Methods: The study included a cohort of 105 newborns and their 99 mothers. Determination of variants of the genes eNOS (G894T, rs1799983) and IL1B (C3953T, rs1143634) was carried out for the patients of study groups.

Results: Results: The frequency of detection of the 894TT genotype by the eNOS gene was increased in newborns with severe asphyxia (p=0.018) and in their mothers (p=0,0057). Further analysis of intergenic interactions, performed in mother-child pairs, revealed an increased frequency of the neonatal 894GG (eNOS)/maternal 3953С (IL-1B) genotype combination in the comparison group versus the group of newborns with HIE (p=0.007).

Conclusion: Conclusions: The significance of the intergenic maternal combination of 894GG/3953CT genotypes for the eNOS and IL1B genes and the intergenic combination of neonatal 894GG (eNOS)/maternal 3953CT (IL-1B) genotypes in the development of HIE in newborns has been proven. Associations of maternal and neonatal 894TT genotypes for the eNOS gene with the development of severe asphyxia, bradycardia, and respiratory failure were found in newborns with HIE.

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母婴NOS3 （rs1799983）、IL1B （rs1143634）基因变异及其基因间相互作用对新生儿缺氧缺血性脑病发展影响及治疗方案的初步研究

目的：探讨eNOS基因（G894T、rs1799983）和IL1B基因（C3953T、rs1143634）母、新生儿变异及其基因间相互作用对新生儿HIE发病的影响。患者和方法：材料和方法：本研究包括105名新生儿及其99名母亲。对研究组患者进行eNOS基因（G894T, rs1799983）和IL1B基因（C3953T, rs1143634）的变异检测。结果：eNOS基因在重度窒息新生儿及其母亲中检测894TT基因型的频率均增高（p=0.018），差异有统计学意义（p= 0.0057）。在母婴对中进行的基因间相互作用进一步分析显示，与HIE新生儿组相比，对照组新生儿894GG (eNOS)/母亲3953С （IL-1B）基因型组合的频率增加（p=0.007）。结论：证实了eNOS和IL1B基因的母体894GG/3953CT基因型基因间组合以及新生儿894GG (eNOS)/母体3953CT （IL-1B）基因型基因间组合在新生儿HIE发病中的意义。在HIE新生儿中发现eNOS基因894TT基因型与严重窒息、心动过缓和呼吸衰竭的发生相关。

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来源期刊

Wiadomosci lekarskie Medicine-Medicine (all)

CiteScore

0.80

自引率

0.00%

发文量

482