Nomenclature for Factors of the HLA System, Update October, November and December 2024

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2025-01-28 DOI:10.1111/iji.12707

Steven G. E. Marsh

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引用次数: 0

Abstract

The following sequences have been submitted to the Nomenclature Committee since the July, August and September 2024 nomenclature update (Marsh, 2024) and, following agreed policy, have been assigned official allele designations (Marsh et al. 2010). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given, and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case, you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

The DRB1*15:13 allele has had a Q suffix added in December 2024, now making it DRB1*15:13Q, as it was recognised in having the same amino acid deletion as had previously been described in the DRB1*11:272Q allele. The C*04:09N allele has had its suffix changed from N to L in December 2024 and is now designated C*04:09L based on information published recently indicating that this allele showed detectable levels of expression (Welters et al. 2024). A further 6 alleles, MICA*023, MICA*026, MICA*036, MICB*005:04, MICB*005:02:02 and MICB*002:01:34 were all deleted in October 2024 following the resequencing of the original material in which these alleles were first described.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLA Database using the sequence submission tool provided (Barker et al. 2023; Robinson, Barker, and Marsh 2024). The IPD-IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla

The author declares no conflicts of interest.

查看原文本刊更多论文

HLA系统因子命名法，2024年10月、11月和12月更新。

自2024年7月、8月和9月命名更新以来，以下序列已提交给命名委员会（Marsh, 2024），并根据商定的政策，已被分配官方等位基因名称（Marsh et al. 2010）。所有序列的全部细节将在即将发布的报告中公布。下面列出了新分配的序列（表1）和先前报告的序列确认（表2）。给出了每个序列的加入号，这些可以用于从EMBL， GenBank或DDBJ数据库中检索序列文件。虽然数据库已经分配了入库号，并且大多数序列已经可用，但仍有可能作者可能尚未允许该序列被释放；在这种情况下，您必须直接与提交作者联系。与新序列有关的附加信息通常包含在描述这些等位基因的出版物中；表3列出了最近发表的描述新的HLA序列的文章。DRB1*15:13等位基因在2024年12月增加了一个Q后缀，现在使其成为DRB1*15:13Q，因为它被认为具有与先前在DRB1*11:272Q等位基因中描述的相同的氨基酸缺失。2024年12月，C*04:09N等位基因的后缀从N变为L，根据最近公布的信息，该等位基因显示出可检测的表达水平，现在被指定为C*04:09L （Welters et al. 2024）。另外6个等位基因MICA*023、MICA*026、MICA*036、MICB*005:04、MICB*005:02:02和MICB*002:01:34均在2024年10月通过对原始材料的重测序被删除。所有新的和确认的序列现在应使用提供的序列提交工具，通过IPD-IMGT/HLA数据库直接提交给世卫组织HLA系统因子命名委员会(Barker等人，2023；罗宾逊，巴克和马什2024)。IPD-IMGT/HLA数据库可通过万维网访问：www.ebi.ac.uk/ipd/imgt/hlaThe。作者声明无利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.