Immune checkpoint inhibitors plus taxane-based chemotherapy for patients with advanced/metastatic NSCLC: a systematic review and meta-analysis across different PD-L1 expression levels.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI:10.1080/14737140.2025.2460537

Aws Khalid Abushanab, Mus'ab Theeb Mustafa, Mahmoud Taysir Mousa, Renad Fawwaz Albanawi, Razan Mohammad Alkhalaileh, Ghaith Nahar Alqudah, Razan Feras Abu Zaina, Zaina Ammar Abu Sitta, Issa Mohammad Almasri, Dua Abuquteish

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引用次数: 0

Abstract

Background: Immune checkpoint inhibitors (ICIs) are currently the primary approach for managing NSCLC. However, numerous combination therapies are currently under investigation. Our goal is to investigate the overall efficacy and safety of ICIs and taxane-based chemotherapy.

Methods: We conducted a systematic review and meta-analysis, searching web databases for relevant literature. We limited our eligibility to phase II/III randomized clinical trials involving advanced/metastatic NSCLC patients.

Results: We performed a meta-analysis encompassing nineteen studies derived from sixteen RCTs. For patients with sq-NSCLC PD-L1 ≥ 50%, using ICIs plus taxane significantly improve PFS and OS with HR of 0.58 (95% CI, 0.45-0.74, p < 0.0001) and 0.41 (95% CI, 0.33-0.50, p < 0.00001), respectively. For patients with non-sq NSCLC PD-L1 1-49%, the analysis revealed significant improvement of OS and PFS with HR of 0.64 (95% CI, 0.47-0.88, p = 0.005) and 0.62 (95% CI, 0.47-0.81, p = 0.0004), respectively. For TRAEs of all grades, ICIs plus taxane resulted with no significant difference compared to control group with risk ratio (RR) 1.00 (95% CI 0.99-1.02).

Conclusion: The analysis revealed significant improvement in efficacy of ICIs with taxane in advanced/metastatic NSCLC patients compared with ICI/taxane monotherapy.Registration: PROSPERO (CRD42023447532).

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免疫检查点抑制剂加紫杉烷化疗治疗晚期/转移性非小细胞肺癌：不同PD-L1表达水平的系统回顾和荟萃分析

背景：免疫检查点抑制剂（ICIs）是目前治疗非小细胞肺癌的主要方法。然而，许多联合疗法目前正在研究中。我们的目标是研究ICIs和紫杉烷化疗的总体疗效和安全性。方法：我们进行了系统综述和荟萃分析，并在网络数据库中检索相关文献。我们将入选资格限制为涉及晚期/转移性NSCLC患者的II/III期随机临床试验。结果：我们进行了一项meta分析，包括来自16项随机对照试验的19项研究。对于sq-NSCLC PD-L1≥50%的患者，使用ICIs +紫杉烷可显著改善PFS和OS， HR分别为0.58 （95% CI, 0.45 - 0.74, p p p = 0.005）和0.62 （95% CI, 0.47 - 0.81, p = 0.0004）。对于所有级别的trae， ICIs加紫杉烷与对照组相比无显著差异，风险比（RR）为1.00 （95% CI 0.99-1.02）。结论：分析显示，与ICI/紫杉烷单药治疗相比，ICI联合紫杉烷治疗晚期/转移性NSCLC患者的疗效有显著提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.