Pyoderma Gangrenosum Improved with Dapsone and Prednisone: A Case Report.

IF 1.7 4区 医学 Q3 DERMATOLOGY
Advances in Skin & Wound Care Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI:10.1097/ASW.0000000000000250
Arbie Sofia P Merilleno, Charlene Marie Ang-Tiu
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引用次数: 0

Abstract

Abstract: Pyoderma gangrenosum is a rare ulcerative condition that poses diagnostic and therapeutic challenges. Diagnosis and appropriate management are often delayed due to its rarity and the presence of numerous clinical variants. In this case report, the authors present the case of a 36-year-old man who had long-standing and nonhealing ulcers that did not respond to multiple antibiotics and serial wound debridement. The patient was promptly initiated on oral corticosteroids and dapsone as an adjunctive steroid agent. After 6 months, the patient reported complete resolution of the lesions. This rare case underscores the potential value of combining prednisone and dapsone as a treatment option for pyoderma gangrenosum, particularly in resource-limited settings.

氨苯砜与强的松联合治疗坏疽性脓皮病1例。
摘要:坏疽性脓皮病是一种罕见的溃疡性疾病,对诊断和治疗提出了挑战。诊断和适当的管理往往延迟,因为它的罕见和存在许多临床变异。在这个病例报告中,作者提出了一个36岁的男性的病例,他有长期和不愈合的溃疡,对多种抗生素和连续伤口清创没有反应。患者立即开始口服皮质类固醇和氨苯砜作为辅助类固醇药物。6个月后,患者报告病灶完全消退。这一罕见病例强调了强的松和氨苯砜联合治疗坏疽性脓皮病的潜在价值,特别是在资源有限的情况下。
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来源期刊
Advances in Skin & Wound Care
Advances in Skin & Wound Care DERMATOLOGY-NURSING
CiteScore
2.50
自引率
12.50%
发文量
271
审稿时长
>12 weeks
期刊介绍: A peer-reviewed, multidisciplinary journal, Advances in Skin & Wound Care is highly regarded for its unique balance of cutting-edge original research and practical clinical management articles on wounds and other problems of skin integrity. Each issue features CME/CE for physicians and nurses, the first journal in the field to regularly offer continuing education for both disciplines.
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