Zirconium-doped iron oxide nanoparticles for enhanced peroxidase-like activity

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-27 DOI:10.1016/j.talanta.2025.127629

Peng Hu, Mengxiang Li, Su Li, Shengqiang Wang

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引用次数: 0

Abstract

Fe₃O₄ nanoparticles (NPs) have emerged as pioneering nanozymes with applications in clinical diagnosis, environmental protection and biosensing. However, it is currently limited by insufficient catalytic activity due to poor electron transfer. In this study, we synthesized electron-rich-Zr-doped defect-rich Fe₃O₄ NPs (Zr₃Fe₃O₄) using a one-pot solvothermal method. Compared with intrinsic Fe₃O₄ NPs, the resultant Zr₃Fe₃O₄ NPs exhibit enhanced peroxidase (POD)-like activity attributed to the presence of active centers of Zr-O-Fe bridges and adsorption sites of asymmetric oxygen vacancies (OVs) Zr-OVs-Fe. The Zr-O-Fe bridges facilitate electron transfer from Zr to Fe, promoting the regeneration of surface Fe²⁺ in Fe₃O₄ NPs. Furthermore, the rich Zr-OVs-Fe significantly enhances the adsorption and electron transfer between catalyst and substrates, thereby regulating the generation pathway of ¹O₂. Leveraging the remarkable POD-like activity of Zr₃Fe₃O₄ NPs, we developed a tandem enzyme-catalyzed reaction for colorimetric detection of glucose. This strategy of constructing active centers by atom doping provides valuable guidance for the development of more efficient Fenton-like catalytic systems with broad applications on a large scale.

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.