The Characteristics of the Metabolomic Profile in Patients with Parkinson's Disease and Vascular Parkinsonism.

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2024-10-01 DOI:10.32607/actanaturae.27511

E V Predtechenskaya, A D Rogachev, P M Melnikova

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Abstract

The gradually increasing age of the world population implies that the prevalence of neurodegenerative diseases also continues to rise. These diseases are characterized by a progressive loss of cognitive and motor functions. Parkinson's disease, which involves the gradual death of specialized neural tissue, is a striking example of a neurodegenerative process. The pathomorphological analysis shows that chronic cerebral ischemia is accompanied by extensive complex neurodegeneration; parkinsonism is its clinical manifestation in 20-30% of cases. Although Parkinson's disease and vascular parkinsonism are similar, these two pathologies have fundamentally different etiopathogeneses. But their set of differential diagnosis traits is confined to some features of the neurological status. There currently exist no diagnostic markers for individual neurodegenerative pathologies or the neurodegeneration phenomenon in general. Metabolomic profiling can be a promising means for finding a unique "fingerprint" of the disease. Identifying the biomarkers of various neurodegenerative diseases will help shorten the time to the diagnosis, forecast the course of the disease, and personalize the therapeutic approach. This review summarizes and compares the current concepts of metabolomics research into Parkinson's disease and vascular parkinsonism, as well as the respective animal models.

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帕金森病和血管性帕金森病患者的代谢组学特征

世界人口年龄的逐渐增长意味着神经退行性疾病的患病率也在继续上升。这些疾病的特点是认知和运动功能的逐渐丧失。帕金森氏症是神经退行性过程的一个显著例子，它涉及特殊神经组织的逐渐死亡。病理形态学分析显示慢性脑缺血伴广泛的复杂神经变性；20-30%的病例临床表现为帕金森病。虽然帕金森病和血管性帕金森病是相似的，但这两种病理有根本不同的病因。但他们的鉴别诊断特征仅限于神经状态的一些特征。目前还没有针对个别神经退行性病理或一般神经退行性现象的诊断标记物。代谢组学分析可能是寻找疾病独特“指纹”的一种很有前途的方法。识别各种神经退行性疾病的生物标志物将有助于缩短诊断时间，预测疾病的病程，并个性化治疗方法。本文对代谢组学在帕金森病和血管性帕金森病的研究现状及动物模型进行了综述和比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.