Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes

IF 6.7 1区 医学 Q1 NEUROSCIENCES
Alfonso Enrique Martinez-Nunez, Hunter Hutchinson, Patricia Coutinho, Filipe Pereira Sarmento, Venkat Srikar Lavu, Qingqi Yuan, Jagan Mohan Reddy Dwarampudi, Aysegul Gunduz, Gregory M. Pontone, Michael S. Okun, Joshua K. Wong
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Abstract

Non-motor symptoms (NMS) in Parkinson’s disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and cognitive decline. This study explores how early RBD can predict the development of NMS profiles in patients, comparing those with and without early RBD. We identified a unique NMS profile associated with early RBD. These patients had a higher rate of cognitive impairment (M2 = 326.84, p < 0.001), apathy (M2 = 332.93, p < 0.001), hallucinations (M2 = 480.05, p < 0.001), depression (M2 = 480.05, p < 0.0001), anxiety (corrected p < 0.01), impulse control disorders (M2 = 77.577, p < 0.001), and autonomic dysfunction (F = 251.8, p < 0001). A survival analysis revealed an association between early RBD and faster progression to cognitive impairment. These NMS profiles may play a critical role in stratifying patients for targeted interventions.

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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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