Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong
{"title":"A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques","authors":"Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong","doi":"10.1002/jbio.202400481","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>In this study, a non-invasive device based on ultraviolet differential absorption spectroscopy (UV-DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups of patients with lung cancer, nodules, and other disease. The results showed that FeNO concentrations were significantly higher in patients with malignant tumours than in healthy controls (<i>p</i> < 0.01). The diagnostic efficacy of FeNO in different lung diseases was confirmed by ROC analysis: the AUC values were 0.925 for malignant tumours, 0.925 for suspected malignant/benign tumours, 0.792 for benign lesions, and 0.938 for infectious/inflammatory diseases. The significant postoperative FeNO level decrease supports the diagnostic use of FeNO in different stages of the disease. Compared with conventional electrochemical, chemiluminescent and fluorescent probe methods, the UV-DOAS technique has significant advantages regarding sensitivity and portability, suggesting its potential for clinical application.</p>\n </div>","PeriodicalId":184,"journal":{"name":"Journal of Biophotonics","volume":"18 4","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biophotonics","FirstCategoryId":"101","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbio.202400481","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, a non-invasive device based on ultraviolet differential absorption spectroscopy (UV-DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups of patients with lung cancer, nodules, and other disease. The results showed that FeNO concentrations were significantly higher in patients with malignant tumours than in healthy controls (p < 0.01). The diagnostic efficacy of FeNO in different lung diseases was confirmed by ROC analysis: the AUC values were 0.925 for malignant tumours, 0.925 for suspected malignant/benign tumours, 0.792 for benign lesions, and 0.938 for infectious/inflammatory diseases. The significant postoperative FeNO level decrease supports the diagnostic use of FeNO in different stages of the disease. Compared with conventional electrochemical, chemiluminescent and fluorescent probe methods, the UV-DOAS technique has significant advantages regarding sensitivity and portability, suggesting its potential for clinical application.
期刊介绍:
The first international journal dedicated to publishing reviews and original articles from this exciting field, the Journal of Biophotonics covers the broad range of research on interactions between light and biological material. The journal offers a platform where the physicist communicates with the biologist and where the clinical practitioner learns about the latest tools for the diagnosis of diseases. As such, the journal is highly interdisciplinary, publishing cutting edge research in the fields of life sciences, medicine, physics, chemistry, and engineering. The coverage extends from fundamental research to specific developments, while also including the latest applications.