[WHO classification of melanocytic tumours].

Abstract

Background: The update of the World Health Organisation (WHO) classification of skin tumours has led to new aspects in the classification of melanocytic tumours.

Objectives: Presentation of the classification of melanocytic tumours in light of current clinical, histological and genetic data.

Materials and methods: Review of the classification of melanocytic neoplasms in the fifth edition of the WHO classification of skin tumours, taking into account current disease concepts.

Results: Malignant melanoma is characterised by stepwise tumour progression and is a heterogeneous disease. Benign and intermediate precursor lesions with characteristic driver mutations can be defined for the different melanoma subtypes. Melanocytomas represent a growing group of intermediate neoplasms which, from a genetic point of view, lie between nevi and melanomas and usually have a benign course.

Conclusion: With the update of the WHO classification, genetic parameters are becoming increasingly relevant and shape the terminology. New terms such as 'melanocytoma' require a medical understanding of current disease concepts and good physician-patient communication for appropriate reporting of findings and therapy.