Model construction and clinical therapeutic potential of engineered cardiac organoids for cardiovascular diseases.

Biomaterials Translational Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.12336/biomatertransl.2024.04.002
Yongtao Wang, Yan Hou, Tian Hao, Marta Garcia-Contreras, Guoping Li, Dragos Cretoiu, Junjie Xiao
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引用次数: 0

Abstract

Cardiovascular diseases cause significant morbidity and mortality worldwide. Engineered cardiac organoids are being developed and used to replicate cardiac tissues supporting cardiac morphogenesis and development. These organoids have applications in drug screening, cardiac disease models and regenerative medicine. Therefore, a thorough understanding of cardiac organoids and a comprehensive overview of their development are essential for cardiac tissue engineering. This review summarises different types of cardiac organoids used to explore cardiac function, including those based on co-culture, aggregation, scaffolds, and geometries. The self-assembly of monolayers, multilayers and aggravated cardiomyocytes forms biofunctional cell aggregates in cardiac organoids, elucidating the formation mechanism of scaffold-free cardiac organoids. In contrast, scaffolds such as decellularised extracellular matrices, three-dimensional hydrogels and bioprinting techniques provide a supportive framework for cardiac organoids, playing a crucial role in cardiac development. Different geometries are engineered to create cardiac organoids, facilitating the investigation of intrinsic communication between cardiac organoids and biomechanical pathways. Additionally, this review emphasises the relationship between cardiac organoids and the cardiac system, and evaluates their clinical applications. This review aims to provide valuable insights into the study of three-dimensional cardiac organoids and their clinical potential.

心血管疾病在世界范围内造成了严重的发病率和死亡率。工程心脏类器官正在被开发并用于复制心脏组织,支持心脏的形态发生和发育。这些类器官在药物筛选、心脏病模型和再生医学中有应用。因此,深入了解心脏类器官及其发展概况对心脏组织工程至关重要。本文综述了用于研究心脏功能的不同类型的类心脏器官,包括基于共培养、聚集、支架和几何形状的类心脏器官。单层、多层和强化心肌细胞的自组装在心脏类器官中形成生物功能细胞聚集体,阐明了无支架心脏类器官的形成机制。相比之下,诸如脱细胞细胞外基质、三维水凝胶和生物打印技术等支架为心脏类器官提供了支持框架,在心脏发育中起着至关重要的作用。不同的几何形状被设计成心脏类器官,促进了心脏类器官和生物力学途径之间内在交流的研究。此外,本文还综述了心脏类器官与心脏系统的关系,并对其临床应用进行了评价。本文综述旨在为三维心脏类器官的研究及其临床潜力提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.70
自引率
0.00%
发文量
9
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