Cardiac organ chip: advances in construction and application.

Biomaterials Translational Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI:10.12336/biomatertransl.2024.04.006
Jun Li, Honghao Hou, Qian Li, Junjie Liu, Yunlong Zhao, Chaoran Zhao, Zhentao Li, Leyu Wang, Xiaozhong Qiu
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Abstract

Cardiovascular diseases are a leading cause of death worldwide, and effective treatment for cardiac disease has been a research focal point. Although the development of new drugs and strategies has never ceased, the existing drug development process relies primarily on rodent models such as mice, which have significant shortcomings in predicting human responses. Therefore, human-based in vitro cardiac tissue models are considered to simulate physiological and functional characteristics more effectively, advancing disease treatment and drug development. The microfluidic device simulates the physiological functions and pathological states of the human heart by culture, thereby reducing the need for animal experimentation and enhancing the efficiency and accuracy of the research. The basic framework of cardiac chips typically includes multiple functional units, effectively simulating different parts of the heart and allowing the observation of cardiac cell growth and responses under various drug treatments and disease conditions. To date, cardiac chips have demonstrated significant application value in drug development, toxicology testing, and the construction of cardiac disease models; they not only accelerate drug screening but also provide a new research platform for understanding cardiac diseases. In the future, with advancements in functionality, integration, and personalised medicine, cardiac chips will further simulate multiorgan systems, becoming vital tools for disease modelling and precision medicine. Here, we emphasised the development history of cardiac organ chips, highlighted the material selection and construction strategy of cardiac organ chip electrodes and hydrogels, introduced the current application scenarios of cardiac organ chips, and discussed the development opportunities and prospects for their of biomedical applications.

心脏器官芯片:构建与应用进展。
心血管疾病是世界范围内死亡的主要原因,有效治疗心血管疾病一直是研究的焦点。尽管新药物和新策略的开发从未停止,但现有的药物开发过程主要依赖于啮齿动物模型,如小鼠,在预测人类反应方面存在重大缺陷。因此,基于人的体外心脏组织模型被认为可以更有效地模拟生理和功能特征,促进疾病治疗和药物开发。微流控装置通过培养模拟人类心脏的生理功能和病理状态,从而减少了对动物实验的需要,提高了研究的效率和准确性。心脏芯片的基本框架通常包括多个功能单元,有效地模拟心脏的不同部位,并允许观察心脏细胞在各种药物治疗和疾病条件下的生长和反应。迄今为止,心脏芯片在药物开发、毒理学测试和心脏病模型构建等方面显示出重要的应用价值;它们不仅加速了药物筛选,而且为了解心脏疾病提供了新的研究平台。在未来,随着功能、集成和个性化医疗的进步,心脏芯片将进一步模拟多器官系统,成为疾病建模和精准医疗的重要工具。在这里,我们重点介绍了心脏器官芯片的发展历史,重点介绍了心脏器官芯片电极和水凝胶的材料选择和构建策略,介绍了心脏器官芯片目前的应用场景,并讨论了心脏器官芯片在生物医学应用方面的发展机遇和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.70
自引率
0.00%
发文量
9
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