A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.

IF 4 2区 生物学 Q1 GENETICS & HEREDITY
PLoS Genetics Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI:10.1371/journal.pgen.1011580
Jia Li, Ruoling Bai, Yulian Zhou, Xu Song, Ling Li
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引用次数: 0

Abstract

A bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. However, role of mitochondrial-derived lncRNAs (mtlncRNAs) in the mitochondria-to-nucleus retrograde regulation remains elusive. Here, we identify functional implication of the mtlncRNAs MDL1AS, lncND5 and lncCyt b in retrograde regulation. Mediated by HuR and PNPT1 proteins, the mtlncRNAs undergo a mitochondria-to-nucleus traveling and then regulate a network of nuclear genes. Moreover, as an example of the functional consequence, we showed that the nuclear-translocated lncCyt b cooperates with the splicing factor hnRNPA2B1 to influence several aspects of cell metabolism including glycolysis, possibly through their regulatory effect on the post-transcriptional processing of related nuclear genes. This study advances our knowledge in mitochondrial biology and provides new insights into the role of mtlncRNAs in mitochondria-nucleus communications.

核易位线粒体lncrna介导的线粒体到细胞核的调控。
细胞核与线粒体的双向通讯对体内平衡和应激至关重要。作为关键分子,核编码lncRNAs (nulncRNAs)参与了核到线粒体的顺行调控。然而,线粒体来源的lncRNAs (mtlncRNAs)在线粒体到细胞核的逆行调节中的作用仍然难以捉摸。在这里,我们确定了mnlcrnas MDL1AS, lncND5和lnccyb在逆行调控中的功能含义。mtlncrna由HuR和PNPT1蛋白介导,经历线粒体到细胞核的旅行,然后调节核基因网络。此外,作为功能后果的一个例子,我们发现核易位的lnccyb与剪接因子hnRNPA2B1合作,影响细胞代谢的几个方面,包括糖酵解,可能是通过它们对相关核基因转录后加工的调节作用。这项研究提高了我们对线粒体生物学的认识,并为mtncrnas在线粒体-细胞核通讯中的作用提供了新的见解。
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来源期刊
PLoS Genetics
PLoS Genetics GENETICS & HEREDITY-
自引率
2.20%
发文量
438
期刊介绍: PLOS Genetics is run by an international Editorial Board, headed by the Editors-in-Chief, Greg Barsh (HudsonAlpha Institute of Biotechnology, and Stanford University School of Medicine) and Greg Copenhaver (The University of North Carolina at Chapel Hill). Articles published in PLOS Genetics are archived in PubMed Central and cited in PubMed.
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