β-Caryophyllene and Statins in Bone Fracture Healing - A Narrative Review.

IF 1.7 Q2 ORTHOPEDICS
Orthopedic Research and Reviews Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI:10.2147/ORR.S506427
Hilik Marom, Mansoor A Khan, Nissim Darvish, Paul Tornetta Iii, Amal Khoury, Yoram A Weil, Nathan W M Skelley, Daniel C Allison, Sahar Meiron, Tami Ehrmann Barr
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引用次数: 0

Abstract

Bone fractures are a leading cause of morbidity and healthcare expenditure globally. The complex healing process involves inflammation, cartilage formation, mineralization, and bone remodeling. Current treatments like immobilization, surgery, and bone grafting, though effective, pose significant challenges, such as prolonged recovery and high costs. Emerging therapies such as biological agents, pharmacological treatments, and physical stimulation techniques are also associated with high costs, side effects, and practical applicability limitations. There is a critical need for alternative therapies that are cost-effective, safe, and easy to use. Recent studies suggest the potential of β-caryophyllene (BCP) and statins in promoting bone healing. BCP, a naturally occurring anti-inflammatory and antioxidant compound found in essential oils, enhances osteoblast activity and inhibits osteoclastogenesis. Statins, known for their cholesterol-lowering effects, also promote bone formation and reduce bone resorption through multiple biochemical pathways. Both BCP and statins have shown promising results in preclinical studies, enhancing bone density and promoting fracture healing. This review explores the individual and potential synergistic effects of BCP and statins on bone fracture healing. It highlights the complementary mechanisms of these agents: BCP's anti-inflammatory and osteogenic properties and statins' ability to inhibit osteoclast activity and promote angiogenesis. Combining BCP and statins could offer a multifaceted approach to enhance fracture healing, reduce complications, and improve patient outcomes. While individual effects are supported preclinically, further studies investigating synergies, formulations, and clinical translation are needed to develop this promising novel therapeutic approach for improving fracture repair outcomes.

β-石竹烯和他汀类药物在骨折愈合中的作用。
骨折是全球发病率和医疗保健支出的主要原因。复杂的愈合过程包括炎症、软骨形成、矿化和骨重塑。目前的治疗方法,如固定、手术和植骨,虽然有效,但也带来了重大挑战,如恢复时间长和费用高。新兴疗法,如生物制剂、药物治疗和物理刺激技术,也与高成本、副作用和实际适用性限制有关。迫切需要成本效益高、安全且易于使用的替代疗法。最近的研究表明,β-石竹烯(BCP)和他汀类药物在促进骨愈合方面具有潜力。BCP是一种天然存在的抗炎和抗氧化化合物,存在于精油中,可以增强成骨细胞的活性,抑制破骨细胞的生成。他汀类药物,以其降胆固醇作用而闻名,也通过多种生化途径促进骨形成和减少骨吸收。BCP和他汀类药物在临床前研究中都显示出良好的效果,可以增强骨密度,促进骨折愈合。这篇综述探讨了BCP和他汀类药物对骨折愈合的个体和潜在的协同作用。它强调了这些药物的互补机制:BCP的抗炎和成骨特性以及他汀类药物抑制破骨细胞活性和促进血管生成的能力。BCP联合他汀类药物可以提供多方面的方法来促进骨折愈合,减少并发症,改善患者预后。虽然个体效应在临床前得到了支持,但需要进一步研究协同作用、配方和临床转化,以开发这种有希望的新型治疗方法,以改善骨折修复效果。
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来源期刊
Orthopedic Research and Reviews
Orthopedic Research and Reviews Medicine-Orthopedics and Sports Medicine
CiteScore
2.80
自引率
0.00%
发文量
51
审稿时长
16 weeks
期刊介绍: Orthopedic Research and Reviews is an international, peer-reviewed, open-access journal focusing on the patho-physiology of the musculoskeletal system, trauma, surgery and other corrective interventions to restore mobility and function. Advances in new technologies, materials, techniques and pharmacological agents will be particularly welcome. Specific topics covered in the journal include: Patho-physiology and bioengineering, Technologies and materials science, Surgical techniques, including robotics, Trauma management and care, Treatment including pharmacological and non-pharmacological, Rehabilitation and Multidisciplinarian care approaches, Patient quality of life, satisfaction and preference, Health economic evaluations. The journal welcomes submitted papers covering original research, basic science and technology, clinical studies, reviews and evaluations, guidelines, expert opinion and commentary, case reports and extended reports.
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