Silent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth?

IF 0.8 Q4 UROLOGY & NEPHROLOGY

Indian Journal of Nephrology Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI:10.25259/ijn_503_23

Ahmed ElSaeed Abdulgalil, Ola H Elnagdy, Noha H Elnagdy, Eman Nagy

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Abstract

Background: It has been claimed that tacrolimus may have harmful effects on the auditory system, where it has been linked to ototoxicity and sensorineural hearing loss (SNHL). We evaluated silent SNHL in kidney transplant recipients (KTRs) receiving tacrolimus and the different factors affecting it compared to healthy controls.

Materials and methods: In this case control study, hearing functions were studied in 42 KTRs receiving tacrolimus as maintenance immunosuppressive therapy for more than 3 months in comparison to 27 age- and gender-matched healthy subjects using tympanometry, pure-tone audiometry (PTA), extended high frequency audiometry (EHFA), and transient evoked oto-acoustic emissions (TEOAEs). Also, different factors were studied in relation to SNHL.

Results: PTA showed that 23.8%, 21.4%, and 4.8% had mild, moderate, and severe SNHL, respectively. One-fifth of KTRs had severe SNHL, according to EHFA. According to TEOAEs, 28.6% of KTRs had abnormal hearing. There was a significant positive correlation between the tacrolimus trough levels and the results of both the PTA (P = 0.002) and EHFA (P = 0.035) tests.

Conclusion: SNHL was detected in about half of the studied KTRs. Silent SNHL in KTRs might be associated with higher tacrolimus trough levels.

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接受他克莫司肾移植患者的无声性听力损失：事实还是神话？

背景：他克莫司可能对听觉系统有有害影响，与耳毒性和感音神经性听力损失（SNHL）有关。我们评估了接受他克莫司治疗的肾移植受者（KTRs）的无症状SNHL，以及与健康对照组相比的不同影响因素。材料和方法：在本病例对照研究中，研究了42例接受他克莫司作为维持免疫抑制治疗超过3个月的KTRs的听力功能，并与27例年龄和性别匹配的健康受试者进行了比较，使用鼓室测量、纯音测听（PTA）、扩展高频测听（EHFA）和瞬态诱发耳声发射（teoae）。并对SNHL的影响因素进行了研究。结果：PTA显示轻度、中度、重度SNHL分别为23.8%、21.4%和4.8%。根据EHFA的数据，五分之一的ktr患有严重的SNHL。根据teoae， 28.6%的ktr患者有听力异常。他克莫司谷浓度与PTA （P = 0.002）和EHFA （P = 0.035）试验结果呈显著正相关。结论：所研究的ktr中约有一半检测到SNHL。KTRs的无症状SNHL可能与他克莫司谷值升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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