Serum Urate and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Clinical Cardiology Pub Date : 2025-01-27 DOI:10.1002/clc.70089

Shandong Yu, Wei Wang, Yulian Gao, Jun Zhou, Yanpeng Chu

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引用次数: 0

Abstract

Background

Observational studies indicate that serum urate level is associated with atrial fibrillation (AF). However, whether this association is causal remains controversial, due to confounding factors and reverse causality. We aim to evaluate the causal relationship of genetically predicted serum urate level with AF.

Methods

A bidirectional Mendelian randomization (MR) study was performed. Instrumental variables were obtained from the Global Urate Genetics Consortium (110347 individuals). We obtained summary statistics of AF from two genome-wide association studies (GWAS) data sets for AF. Inverse-variance-weighted method was applied to obtain MR estimates and other statistical methods were conducted in the sensitivity analyses. The reverse MR analysis was performed to evaluate the effect of AF on serum urate levels.

Results

Genetically determined serum urate level was not associated with AF in two studies (OR, 1.03; 95% CI, 0.95–1.11; p = 0.47); (OR, 1.06; 95% CI, 0.99–1.12; p = 0.09). The main results kept robust in the most sensitivity analyses. Multivariable MR analyses suggested that the association pattern did not change, after adjusting for body mass index (BMI), HbA1c: hemoglobin A1c (HbA1c), hypertension, low-density lipoprotein cholesterol (LDL-C) and coronary heart disease. No causal effect of AF on serum urate levels was found in two studies (OR, 1.02; 95% CI, 0.98–1.05; p = 0.30); (OR, 1.00; 95% CI, 0.98–1.03; p = 0.95).

Conclusions

Our MR study supports no bidirectional causal effect of serum urate levels and AF. This implies that treatments aimed at lowering uric acid may not reduce the risk of AF.

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血清尿酸和心房颤动：一项双向孟德尔随机研究。

背景：观察性研究表明血清尿酸水平与房颤（AF）相关。然而，由于混杂因素和反向因果关系，这种关联是否存在因果关系仍然存在争议。我们的目的是评估遗传预测血清尿酸水平与af的因果关系。方法：进行双向孟德尔随机化（MR）研究。工具变量来自Global Urate Genetics Consortium（110347个个体）。我们从两个全基因组关联研究（GWAS）的AF数据集中获得AF的汇总统计数据。采用反方差加权法获得MR估计值，并采用其他统计方法进行敏感性分析。反向磁共振分析评估房颤对血清尿酸水平的影响。结果：在两项研究中，基因决定的血清尿酸水平与房颤无关(OR, 1.03；95% ci, 0.95-1.11；p = 0.47)；(优势比,1.06;95% ci, 0.99-1.12；p = 0.09)。在大多数敏感性分析中，主要结果保持稳健。多变量MR分析表明，在调整体重指数（BMI）、HbA1c：血红蛋白A1c （HbA1c）、高血压、低密度脂蛋白胆固醇（LDL-C）和冠心病后，这种关联模式没有改变。两项研究未发现房颤对血清尿酸水平的因果影响(OR, 1.02；95% ci, 0.98-1.05；p = 0.30)；(优势比,1.00;95% ci, 0.98-1.03；p = 0.95)。结论：我们的MR研究支持血清尿酸水平与房颤之间没有双向因果关系。这意味着旨在降低尿酸的治疗可能不会降低房颤的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cardiology 医学-心血管系统

CiteScore

5.10

自引率

3.70%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.