Give it time to SOBER up - GITSU- a new strategy in percutaneous coronary intervention for chronic total occlusion.

Abstract

Background: The prevalence of coronary chronic total occlusion (CTO) in coronary angiography (CAG) has risen with ageing populations, along with the expansion of CTO percutaneous coronary interventions (CTO-PCI). However, CTO-PCI encounters challenges such as undersized stents, dissection risks, and limited access to intravascular imaging (IVI), particularly in regions with limited health budgets. This study introduces the 'GIVE IT TIME TO SOBER UP - GITSU strategy', a two-session CTO-PCI approach where Thrombolysis in Myocardial Infarction (TIMI-3) antegrade flow is achieved without stent placement in the first session. We aim to present its key attributes, outcomes, and implications for invasive cardiology.

Methods: Demographic data, CTO lesion characteristics in the first PCI session, procedural features, in-hospital major adverse cardiovascular adverse events (MACE), technical features of the second PCI session, and in-hospital MACE were examined.

Results: We applied the GITSU strategy to 53 CTO lesions between August 2020 and June 2023. The mean lesion length was shortened compared to the first session (21.3 ± 10.5%). There was an increase in mean distal reference vessel diameter (2.52 ± 0.49 mm), and the increase was 24.2%±11.3% compared to the first session. There was 24.4%±11.5% stent length savings. We achieved an increase in stent size of 20.3% to 10.1% compared to the mean stent diameter. The technical success and procedural success rate were 92.5% and 90.6%, respectively.

Conclusion: Patients who underwent GITSU used shorter and wider stents in the second PCI session. This strategy is likely to reduce TLR and ISR rates.