Evasion of T cell responses by newly emerging SARS-CoV-2 variants

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-01-28 DOI:10.1038/s41590-024-02053-y

引用次数: 0

Abstract

We describe how newly emerging mutations in the SARS-CoV-2 variant BA.2.86 sub-variant JN.1 contribute to evasion of CD8+ T cell responses. Mutations occurring in T cell epitope hotspots in the viral spike protein and in a highly conserved site in the viral nucleocapsid suggest that T cell-mediated immune pressure is a key driving force for SARS-CoV-2 evolution and adaptation.

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新出现的SARS-CoV-2变体逃避T细胞反应

我们描述了SARS-CoV-2变体BA.2.86亚变体JN.1中新出现的突变如何有助于逃避CD8+ T细胞反应。在病毒刺突蛋白的T细胞表位热点和病毒核衣壳高度保守位点发生的突变表明，T细胞介导的免疫压力是SARS-CoV-2进化和适应的关键驱动力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.