{"title":"Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer.","authors":"Xiangmei Wu, Lijiang Duan","doi":"10.4103/ijpm.ijpm_277_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities.</p><p><strong>Aims: </strong>To study the expression and correlation of P53 protein and epithelial-mesenchymal transition (EMT) related makers in NSCLC.</p><p><strong>Materials and methods: </strong>32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers.</p><p><strong>Results: </strong>The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05).</p><p><strong>Conclusions: </strong>There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.</p>","PeriodicalId":502106,"journal":{"name":"Indian journal of pathology & microbiology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of pathology & microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijpm.ijpm_277_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities.
Aims: To study the expression and correlation of P53 protein and epithelial-mesenchymal transition (EMT) related makers in NSCLC.
Materials and methods: 32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers.
Results: The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis (P < 0.05). A positive association was found between P53 and EMT (r = 0.380, P < 0.05).
Conclusions: There is a positive association between P53, snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.
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