Amber M Luckett, Richard A Oram, Aaron J Deutsch, Hector I Ortega, Diane P Fraser, Kaavya Ashok, Alisa K Manning, Josep M Mercader, Manuel Rivas, Miriam S Udler, Michael N Weedon, Anna L Gloyn, Seth A Sharp
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引用次数: 0
Abstract
Type 1 diabetes (T1D) polygenic risk scores (PRS) are effective tools for discriminating T1D from other diabetes types and predicting T1D risk, with applications in screening and intervention trials. A previously published T1D Genetic Risk Score 2 (GRS2) is widely adopted, but challenges in standardization and accessibility have hindered broader clinical and research utility. To address this, we introduce GRS2x, a standardized and cross-compatible method for accurate T1D PRS calculation, demonstrating genotyping and reference panel independent performance across diverse datasets. GRS2x as a unified approach facilitates accessible and portable measurement of T1D polygenic risk.
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