Role of zinc homeostasis in the prevention of prostate diseases

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-01-22 DOI:10.1016/j.jtemb.2025.127605

Ziqi Chen , Junsheng Liu , Jing Ma , Xiuqiao Yu , Shusong Wang , Zhenxian Wang

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引用次数: 0

Abstract

The prostate gland is the largest accessory sex gland in the male reproductive system, and is recognized for its elevated zinc concentration. Recently, the incidence of prostate diseases has increased, posing a significant threat to the health of men. Increasing evidence suggests that maintaining normal prostate function requires proper zinc homeostasis. Prostate disease can cause changes in the regulation of zinc levels in the prostate. Studies have indicated that patients with prostatitis, prostate enlargement, or prostate cancer experience an imbalance in zinc homeostasis, resulting in changes in zinc levels in the body and altered distribution of zinc in tissues. Zinc prevents the malignant transformation of normal prostate tissue by blocking citric acid oxidation, inducing apoptosis, and exhibiting antioxidant activity. Therefore, studying changes in zinc homeostasis in prostate diseases is of great clinical value for diagnosing and treating these diseases. This article reviews the distribution and content of zinc in the prostate, the mechanism underlying zinc homeostasis regulation, the role of zinc homeostasis in prostate diseases, and the clinical applications of zinc.

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锌平衡在预防前列腺疾病中的作用。

前列腺是男性生殖系统中最大的辅助性腺，它的锌含量较高。最近，前列腺疾病的发病率有所增加，对男性健康构成重大威胁。越来越多的证据表明，维持正常的前列腺功能需要适当的锌稳态。前列腺疾病会导致前列腺锌水平调节的改变。研究表明，前列腺炎、前列腺肿大或前列腺癌患者体内锌稳态失衡，导致体内锌水平改变，组织中锌分布改变。锌通过阻断柠檬酸氧化、诱导细胞凋亡和显示抗氧化活性来阻止正常前列腺组织的恶性转化。因此，研究前列腺疾病中锌稳态的变化对前列腺疾病的诊断和治疗具有重要的临床价值。本文就锌在前列腺中的分布和含量、锌体内平衡调节的机制、锌体内平衡在前列腺疾病中的作用以及锌的临床应用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.