Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control

IF 4 Q2 NEUROSCIENCES
Mariah DeSerisy , Jacob W. Cohen , Huiyu Yang , Bruce Ramphal , Paige Greenwood , Kahini Mehta , Michael P. Milham , Theodore D. Satterthwaite , David Pagliaccio , Amy E. Margolis
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引用次数: 0

Abstract

Background

Irritability affects up to 20% of youth and is a primary reason for referral to pediatric mental health clinics. Irritability is thought to be associated with disruptions in processing of reward, threat, and cognitive control; however, empirical study of these associations at both the behavioral and neural level have yielded equivocal findings that may be driven by small sample sizes and differences in study design. Associations between irritability and brain connectivity between cognitive control and reward- or threat-processing circuits remain understudied. Furthermore, better inhibitory control has been linked to lower irritability and differential neural functioning among irritable youth, suggesting that good inhibitory control may serve as a protective factor.

Methods

We hypothesized that higher irritability scores would be associated with less positive (or negative) connectivity between cognitive control and threat-processing circuits and between cognitive control and reward-processing circuits in the Healthy Brain Network dataset (release 10.0; N = 4135). We also hypothesized that these associations would be moderated by inhibitory control such that weaker associations between irritability and connectivity would be detected in youths with better than with worse inhibitory control. Regression models were used to test whether associations between irritability and between-network connectivity were moderated by inhibitory control.

Results

Counter to our hypothesis, we detected higher irritability associated with reduced connectivity between threat- and reward-processing and cognitive control networks only in 5- to 9-year-old boys. Inhibitory control did not moderate associations of irritability with between-network connectivity.

Conclusions

Exploratory findings indicate that reduced between-network connectivity may underlie difficulty regulating negative emotions, leading to greater irritability.
烦躁的神经关联及抑制控制的潜在调节作用。
背景:易怒影响高达20%的青少年,是转介到儿科心理健康诊所的主要原因。易怒被认为与奖励、威胁和认知控制过程的中断有关;然而,在行为和神经水平上对这些关联的实证研究产生了模棱两可的结果,这可能是由小样本量和研究设计的差异造成的。在认知控制和奖励或威胁处理回路之间,易怒和大脑连接之间的关联仍未得到充分研究。此外,更好的抑制控制与易怒青年的低易怒和不同的神经功能有关,这表明良好的抑制控制可能是一个保护因素。方法:我们假设较高的易怒得分与认知控制和威胁处理回路之间以及认知控制和奖励处理回路之间较少的正(或负)连通性有关。N = 4135)。我们还假设这些关联会被抑制控制所缓和,因此在抑制控制较好的青少年中,易怒和连通性之间的关联较弱。回归模型被用来检验烦躁和网络间连接之间的关联是否被抑制控制所调节。结果:与我们的假设相反,我们发现只有在5到9岁的男孩中,更高的易怒与威胁和奖励处理以及认知控制网络之间的连接减少有关。抑制性控制并没有调节易怒与网络间连接的关联。结论:探索性研究结果表明,网络间连通性降低可能是调节负面情绪困难的基础,导致更大的易怒。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biological psychiatry global open science
Biological psychiatry global open science Psychiatry and Mental Health
CiteScore
4.00
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