A Preliminary Screening Tool for High-Risk Frailty in Older Adults Patients with Pulmonary Tuberculosis.

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Clinical Interventions in Aging Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI:10.2147/CIA.S493887

Hui-Juan Li, Yue-Ying Zhou, He-He Yu, Jian Jiang, Yu-Wei Cai

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引用次数: 0

Abstract

Objective: To understand the current status and analyse the factors influencing frailty in older adults patients with pulmonary tuberculosis.

Methods: This retrospective case-control study included 204 older adults patients with pulmonary tuberculosis. The enrolled patients were divided into a frailty group (n = 101) and a non-frailty group (n = 103). The study further collected and compared the data of various scores.

Results: The total frailty score among the patients ranged from 0 to 15 points, with an average score of 5.23 ± 2.31 points. The total social support score ranged from 15 to 47 points, with an average of 33.43 ± 6.11 points. The physical function level scores ranged from 10 to 100 points, with an average of 84.58 ± 14.48 points. Additionally, univariate analysis showed significant differences between the groups in terms of age, body mass index (BMI), duration of disease, types of long-term medication and the number of complications and comorbidities (P < 0.05). Correlation analysis revealed negative correlations of social support (P < 0.001) and physical function (P < 0.001) with the overall frailty score and a positive correlation of depression levels (P < 0.001) with the overall frailty score. Further regression analysis indicated that being over 80 years old, having a low BMI, long-term polypharmacy and a high depression score were risk factors. High social support and physical function scores were protective factors against frailty in older adults patients with pulmonary tuberculosis.

Conclusion: In older adults patients with pulmonary tuberculosis, the overall frailty score shows negative correlations with social support and physical function and a positive correlation with depression level.

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老年肺结核患者高危虚弱的初步筛查工具。

目的：了解老年肺结核患者的发病现状，分析影响衰弱的因素。方法：本回顾性病例对照研究纳入204例老年肺结核患者。纳入的患者分为衰弱组（n = 101）和非衰弱组（n = 103）。本研究进一步收集和比较了各种分数的数据。结果：患者衰弱总评分0 ~ 15分，平均5.23±2.31分。社会支持总分在15 ~ 47分之间，平均为33.43±6.11分。身体机能水平评分范围为10 ~ 100分，平均84.58±14.48分。此外，单因素分析显示，两组在年龄、体重指数（BMI）、病程、长期用药类型、并发症及合并症数量等方面差异均有统计学意义（P < 0.05）。相关分析显示，社会支持（P < 0.001）和身体功能（P < 0.001）与总体衰弱评分呈负相关，抑郁水平（P < 0.001）与总体衰弱评分呈正相关。进一步回归分析表明，年龄超过80岁、BMI较低、长期服用多种药物和抑郁评分较高是危险因素。较高的社会支持和身体功能评分是老年肺结核患者对抗虚弱的保护因素。结论：老年肺结核患者虚弱总分与社会支持、身体功能呈负相关，与抑郁水平呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.80

自引率

2.80%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.