Genomic evolution of SARS-CoV-2 in Morocco: Insights from whole genome sequences collected from 2020 to 2024

IF 2.5 4区医学 Q3 VIROLOGY

Virus research Pub Date : 2025-01-31 DOI:10.1016/j.virusres.2025.199530

Hamza GHAMMAZ , Marouane MELLOUL , Ahlam MBARKI , Mouhssine HEMLALI , Taha CHOUATI , Hicham EL ANNAZ , Nadia TOUIL , Mostafa ELOUENNASS , Khalid ENNIBI , Elmostafa EL FAHIME

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引用次数: 0

Abstract

This study investigates the evolution and genetic diversity of SARS-CoV-2 strains circulating in Morocco to track the spread, clade distributions and mutations of the virus across various regions from February 2020 to June 2024. The genome sequences were retrieved from the GISAID database. A total of 2630 SARS-CoV-2 genome sequences were analyzed using bioinformatic tools such as Nextclade, followed by phylogenetic and statistical analyses. The study highlights the predominance of the GRA clade (Omicron variant) since November 2021, while clades such as G, GH, GR, and GRY were identified earlier. The GRA clade exhibited the highest number of non-synonymous mutations, particularly in the Spike (S) gene, suggesting strong evolutionary pressure. The correlation analysis between structural and non-structural proteins revealed key interactions between S and NSP5, providing insights into the viral replication and assembly processes. This work gives new insights to the dynamics of SARS-CoV-2 in Morocco and underscores the importance of ongoing genomic surveillance to respond to emerging variants and potential future outbreaks.

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摩洛哥SARS-CoV-2的基因组进化：来自2020 - 2024年全基因组序列的见解

本研究调查了摩洛哥流行的SARS-CoV-2毒株的进化和遗传多样性，以追踪该病毒在2020年2月至2024年6月期间在各地区的传播、进化支分布和突变。基因组序列从GISAID数据库中检索。利用Nextclade等生物信息学工具对2630个SARS-CoV-2基因组序列进行分析，并进行系统发育和统计分析。该研究强调，自2021年11月以来，GRA分支（Omicron变体）占主导地位，而G、GH、GR和GRY等分支较早被发现。GRA进化支显示出最多的非同义突变，特别是在Spike (S)基因上，表明强大的进化压力。结构蛋白和非结构蛋白之间的相关性分析揭示了S和NSP5之间的关键相互作用，为病毒复制和组装过程提供了见解。这项工作为摩洛哥SARS-CoV-2的动态提供了新的见解，并强调了持续进行基因组监测以应对新出现的变体和潜在的未来疫情的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virus research 医学-病毒学

CiteScore

9.50

自引率

2.00%

发文量

239

审稿时长

43 days

期刊介绍： Virus Research provides a means of fast publication for original papers on fundamental research in virology. Contributions on new developments concerning virus structure, replication, pathogenesis and evolution are encouraged. These include reports describing virus morphology, the function and antigenic analysis of virus structural components, virus genome structure and expression, analysis on virus replication processes, virus evolution in connection with antiviral interventions, effects of viruses on their host cells, particularly on the immune system, and the pathogenesis of virus infections, including oncogene activation and transduction.